文献类型：期刊文献

中文题名：清热逐风方联合依托考昔治疗湿热痹阻型急性痛风性关节炎60例临床观察

英文题名：Clinical observation of Qingre Zhufeng Fang combined with etoricoxib in treating 60 cases of acute gouty arthritis with dampness-heat blockage

作者：李丹丹[1];王海东[1]

第一作者：李丹丹

机构：[1]甘肃中医药大学中医临床学院

第一机构：甘肃中医药大学中医临床学院

年份：2018

卷号：35

期号：1

起止页码：63

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

语种：中文

中文关键词：急性痛风性关节炎;湿热痹阻型;清热逐风方;依托考昔;临床观察

外文关键词：acute gouty arthritis ; syndrome of dampness-heat blockage ; Qingre Zhufeng Fang ; etoricoxib ; clinical observation

摘要：目的观察清热逐风方联合依托考昔治疗湿热痹阻型急性痛风性关节炎的临床疗效。方法将180例湿热痹阻型急性痛风性关节炎患者采用随机数字表法分为3组,即依托考昔组(A组)、清热逐风方组(B组)、清热逐风方联合依托考昔组(C组),各60例,分别给予依托考昔片、清热逐风方、依托考昔片联合清热逐风方治疗。治疗7 d后比较3组的临床疗效及不良反应发生情况,并于治疗前后比较3组各证候积分、血尿酸(UA)、C-反应蛋白(CRP)、血沉(ESR)。结果与同组治疗前比较,3组治疗后关节压痛、关节肿胀、关节活动情况、肤色、局部皮温各证候积分及UA,CRP,ESR均显著降低(P<0.05);与A组治疗后比较,B组和C组各证候积分及UA,ESR,CRP均显著降低(P<0.05);与B组治疗后比较,C组各证候积分及UA,ESR,CRP均显著降低(P<0.05)。A组总有效率为76.67%,B组为83.33%,C组为96.67%,3组组间比较差异均有统计学意义(P<0.05)。3组在治疗过程中均无不良反应发生。结论清热逐风方联合依托考昔治疗湿热痹阻型急性痛风性关节炎疗效显著,具有良好的安全性。
Objective To observe the clinical curative effect of Qingre Zhufeng Fang combined with etoricoxib in treating 60 cases of acute gouty arthritis with dampness-heat blockage. Methods 180 cases of acute gouty arthritis with dampness-heat blockage were randomly divided into group A,treated with etoricoxib; group B,treated with Qingre Zhufeng Fang; group C,intervened with co-administration of both drugs; 60 cases in each. Treating for 7 days,clinical efficiency,adverse reactions,syndrome integrals,blood UA,CRP,ESR were compared among 3 groups before and after treatment. Results After treatment,the syndrome integrals of joint tenderness,swelling,activity,local skin colour and temperature as well as blood UA,CRP,ESR in 3 groups all decreased notably（ P 〈 0. 05）;compared with group A,all indexes in group B and C decreased obviously（ P 〈 0.05）; compared with group B,all indexes in group C dropped（ P 〈 0. 05）. The total effective rates of group A,B and C were 76. 67%,83. 33% and96.67% respectively,there was a significant difference（ P 〈 0.05）.No any adverse reaction came up in the therapeutic process. Conclusion The joint therapy is effective along with a favorable safety in treating acute gouty arthritis with dampness-heat blockages.