文献类型：期刊文献

英文题名：Duality of Interactions Between TGF-beta and TNF-alpha During Tumor Formation

作者：Liu, Zhi-wei[1];Zhang, Yi-ming[1];Zhang, Li-ying[1,2];Zhou, Ting[1];Li, Yang-yang[1];Zhou, Gu-cheng[1];Miao, Zhi-ming[1];Shang, Ming[1];He, Jin-peng[3,4];Ding, Nan-[3,4];Liu, Yong-qi[1,5]

第一作者：Liu, Zhi-wei

通信作者：Liu, YQ[1];Liu, YQ[2]

机构：[1]Gansu Univ Chinese Med, Tradit Chinese Med Res Gansu Coll & Univ, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]First Peoples Hosp Lanzhou City, Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China;[3]Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China;[4]Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Tradit Chinese Med Res Gansu Coll & Univ, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：12

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000751014300001)】；

基金：National Natural Science Foundation of China (No. 81973595); National Natural Science Foundation of China (No. 82004094); Support Program for Longyuan Youth and Fundamental Research Funds for the Universities of Gansu Province. (No. GZTZ[2021]17-1); Provincial university industry support project in Gansu (No. 2020C-15).

语种：英文

外文关键词：TGF-beta; TNF-alpha; proliferation; apoptosis; inflammation; genomic instability; epithelial-mesenchymal transition

摘要：The tumor microenvironment is essential for the formation and development of tumors. Cytokines in the microenvironment may affect the growth, metastasis and prognosis of tumors, and play different roles in different stages of tumors, of which transforming growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha) are critical. The two have synergistic and antagonistic effect on tumor regulation. The inhibition of TGF-beta can promote the formation rate of tumor, while TGF-beta can promote the malignancy of tumor. TNF-alpha was initially determined to be a natural immune serum mediator that can induce tumor hemorrhagic necrosis, it has a wide range of biological activities and can be used clinically as a target to immune diseases as well as tumors. However, there are few reports on the interaction between the two in the tumor microenvironment. This paper combs the biological effect of the two in different aspects of different tumors. We summarized the changes and clinical medication rules of the two in different tissue cells, hoping to provide a new idea for the clinical application of the two cytokines.