文献类型：期刊文献

中文题名：兔气虚血瘀型心力衰竭模型的建立

英文题名：Establishment of The Animal Model of Congestive Heart Failure with Qixu Xueyu syndrome in Rabbits

作者：曹雪滨[1];李培建[1];黄河玲[1];何建成[2];胡元会[3]

第一作者：曹雪滨

机构：[1]解放军二五二医院;[2]甘肃中医学院内科教研室;[3]北京中医药大学博士后活动站

第一机构：解放军二五二医院

年份：1999

卷号：16

期号：3

起止页码：10

中文期刊名：实验动物科学与管理

外文期刊名：LABORATORY ANIMAL SCIENCE AND ADMINISTRATION

语种：中文

中文关键词：充血性心力衰竭;气虚血瘀证;疾病模型

外文关键词：Congestive heart failure\ Qixu Xueyu syndrome\ Animal model\ Disease

摘要：本研究旨在通过反复多次大剂量静脉滴注去甲肾上腺素建立兔气虚血瘀型充血性心力衰竭动物模型。２０ 只兔随机分为模型组与对照组，模型组动物给予去甲肾上腺素（１ｍｇ／ｋｇ） ，间日一次，连续应用１５ 次，对照组动物给予生理盐水。结果证实模型组动物在发生心肌形态学改变的基础上有显著的血流动力学异常，符合充血性心力衰竭的特点。同时模型组动物具有符合中医理论气虚血瘀证的表现，存在血瘀证的客观指标。
? The aim of our study was to establish an animal model of congestive heart failure with Qixu Xueyu syndrome in rabbits. 20 rabbits were divided into a model group and a contral group, and norepinephire were given to rabbits at a dosage of 1mg/kg in the model group. The results suggested that marked myocardial injuries were found in animal of the model group. The ASP\, ADP\, LVSP and ±dp/dtmax in model group were decreased, while the LVEDP was increased. The symptoms of Qixu Xueyu syndrome also existed. Thus, the animal model was succesfully established.