文献类型：期刊文献

英文题名：Core-shell magnetic zeolite imidazolate framework-8 as adsorbent for magnetic solid phase extraction of brucine and strychnine from human urine

作者：Ding, Ya-Wen[1];Jin, Ling[2];Feng, Shi-Lan[1];Chen, Juan[1]

第一作者：Ding, Ya-Wen

通信作者：Feng, SL[1];Chen, J[1]

机构：[1]Lanzhou Univ, Sch Pharm, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Sch Pharm, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Pharm, Lanzhou, Peoples R China.

年份：2021

卷号：1173

外文期刊名：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

收录：;EI(收录号：20211710269482);Scopus(收录号：2-s2.0-85104797163);WOS:【SCI-EXPANDED(收录号:WOS:000652843300004)】；

基金：This work was funded by Special Foundation for National Science and Technology Basic Resources of China (2018FY100701) and the Fourth National General Survey of Traditional Chinese Medicine Resources in Gansu Province.

语种：英文

外文关键词：Brucine; Magnetic solid phase extraction; Magnetic zeolite imidazolate framework-8; Sample preparation; Strychnine

摘要：Core-shell magnetic zeolite imidazolate framework-8 (Fe3O4@PAA@ZIF-8) was successfully synthesized and first employed as adsorbent of magnetic solid-phase extraction (MSPE) for the determination of brucine and strychnine in human urine sample coupled with high performance liquid chromatography. The as-prepared Fe3O4@PAA@ZIF-8 was characterized by transmission electron microscopy, Fourier-transform infrared spectrometry, X-ray diffraction, vibrating sample magnetometer and zeta potential analysis. Main parameters affecting the MSPE efficiency, including amount of adsorbent, sample solution pH, extraction time, ionic strength, desorption solvent, desorption time and desorption volume were further optimized. Under the optimized conditions, the proposed method provided good linearity (5.0-1000.0 mu g L-1) with determination coefficients between 1.0000 and 0.9998, low limits of detection in the range of 1.1-1.2 mu g L-1, and excellent reproducibility with relative standard deviations of less than 7.7%. The intra-day and inter-day precision were 1.5-3.2% and 2.1-7.2%, respectively. Satisfactory spiked recoveries were between 97.2% and 115.4% with the relative standard deviations less than 6.3%. The results demonstrated that Fe3O4@PAA@ZIF-8 composite was a promising magnetic adsorbent for the preconcentration of brucine and strychnine in human urine sample.