文献类型：期刊文献

中文题名：加味补阳还五汤联合醒脑静注射液治疗急性脑出血临床研究

英文题名：Clinical Observation of Modified Buyang Huanwu Tang Combined with Xingnaojing Injection for Acute Cerebral Hemorrhage

作者：吕娟[1];张建平[1];张婷[1];罗十之[2]

第一作者：吕娟

机构：[1]甘肃省中医院,甘肃兰州730500;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃省中医院,甘肃兰州730500

年份：2018

卷号：50

期号：8

起止页码：70

中文期刊名：新中医

外文期刊名：New Chinese Medicine

基金：甘肃中医药大学附属医院院内青年基金项目(ZQ2013-35)

语种：中文

中文关键词：急性脑出血;加味补阳还五汤;醒脑静注射液;格拉斯哥评分(GCS);美国国立研究院卒中量表评分(NIHSS)

外文关键词：Acute cerebral hemorrhage;Modified Buyang Huanwu tang;Xingnaojing injection;Glasgow coma scale （GCS）;National institutes of health stroke scale （NIHSS）

摘要：目的:研究加味补阳还五汤联合醒脑静注射液治疗急性脑出血的临床疗效。方法:将最终完成研究的9 5例急性脑出血患者分为对照组4 6例和治疗组4 9例。2组均给予常规西医治疗,对照组在常规治疗基础上给予醒脑静注射液;治疗组在对照组基础上给予加味补阳还五汤治疗。15天为1疗程,2组均治疗2疗程。比较2组4 8 h血肿扩大率、治疗前后格拉斯哥评分(GCS)和美国国立研究院卒中量表评分(NIHSS)、血清C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、一氧化氮(NO)表达水平及临床疗效。结果:4 8 h血肿扩大率治疗组为6.12%,对照组为19.57%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组GCS、NIHSS评分比较无差异(P>0.05);治疗后,2组GCS评分均较治疗前上升(P<0.05),NIHSS评分均较治疗前下降(P<0.05);治疗组GCS、NIHSS评分与对照组比较,差异均有统计学意义(P<0.05)。治疗前,2组血清CRP、TNF-α、NO表达水平比较无差异(P>0.05);治疗后,2组血清CRP、TNF-α、NO表达水平均较治疗前降低(P<0.05);治疗组血清CRP、TNF-α、NO表达水平较对照组降低更明显(P<0.05)。治疗后,总有效率治疗组为9 1.8%,对照组为82.6%,2组比较,差异有统计学意义(P<0.05)。结论:加味补阳还五汤联合醒脑静注射液可有效预防急性脑出血患者4 8 h血肿扩大,改善患者意识状态,减轻神经损伤,抑制脑出血后炎症反应,临床疗效佳。
Objective： To observe the clinical effect of modified Buyang Huanwu tang combined with Xingnaojing injection for acute cerebral hemorrhage. Methods： Divided 95 cases of patients with acute cerebral hemorrhage into two groups, 46 cases in the control group and 49 cases in the treatment group. Both groups were given the routine western medicine for treatment,while the control group was additionally given Xingnaojing injection,the treatment group was additionally given modified Buyang Huanwu tang based on the treatment for the control group. The treatment for both groups lasted for two courses, 15 days as one course. Compared the enlargement rate of hematoma within 48 h,scores of Glasgow coma scale（GCS） and national institutes of health stroke scale（NIHSS）,the expression of C-reactive protein（CRP）, tumor necrosis factor α（TNF-α）, nitric oxide（NO） in serum, and the clinical effect before and after treatment in both groups. Results：The enlargement rate of hematoma within 48 h was 6.12% in the treatment group and19.57% in the control group,difference being significant（P〈0.05）. Before treatment,there were no significant differences being found in the scores of GCS and NIHSS in both groups（P〈0.05）. After treatment,scores of GCS in both groups were higher than those before treatment（P〈0.05）,and scores of NIHSS in both groups were lower than those before treatment（P〈0.05）,comparing the scores of GCS and NIHSS between the two groups, there were significant differences being found（P〈0.05）. Before treatment, there were no significant differences being found in the expression levels of CPR,TNF-α and NO in both groups（P〈0.05）, after treatment, the expression levels of CPR,TNF-α and NO in both groups were lower than those before treatment（P〈0.05）,the expression levels in the treatment group were decreased more significantly than those in the control group（P〈0.05）. After treatment,the total effective rate was 91.8% in the treatment group and 82.6% in the control group, difference being significant（P〈0.05）. Conclusion： Modified Buyang Huanwu tang combined with Xingnaojing injection can effectively prevent the hematoma enlargement within 48 h of patients with acute cerebral hemorrhage, improve the status of consciousness, reduce nerve injuries and inhibit inflammatory reactions after cerebral hemorrhage,which has good clinical effect.