文献类型：期刊文献

中文题名：瞬时受体电位家族离子通道与四气五味(辛味)的关系研究

英文题名：Relationship between Family Ion Channels of Transient Receptor Potential and Four Properties and Five Tastes(Pungent)

作者：杨丽丽[1,2];宁艳梅[1,2];魏本君[1,2,3];海洋[1,2,4];刘小瑞[1,2];任珂[1,2];刘东玲[1,2]

第一作者：杨丽丽

机构：[1]甘肃中医药大学药学院,兰州730000;[2]西北中藏药协同创新中心,兰州730000;[3]甘肃中医药大学中医临床学院,兰州730000;[4]甘肃中医药大学科研实验中心,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2024

卷号：19

期号：3

起止页码：418

中文期刊名：世界中医药

外文期刊名：World Chinese Medicine

收录：CSTPCD;;北大核心:【北大核心2023】；

基金：国家自然科学基金地区基金项目(81760789);甘肃省教育厅“双一流”科研重点项目(GSSYLXM-05);甘肃中医药大学科创基金重点项目。

语种：中文

中文关键词：瞬时受体电位通道;中药;理论;药性;四气;五味;辛味

外文关键词：Channel of transient receptor potentials;Traditional Chinese medicine;Theory;Medicinal property;Four properties;Five tastes;Pungent

摘要：温度型哺乳动物瞬时受体电位(Transient Receptor Potentials,TRPs)家族离子通道相关受体在人体内广泛分布,参与机体的基础代谢调节,是心血管系统疾病、神经系统疾病及肿瘤等的潜在治疗靶点。现描述不同TRPs家族离子通道感受温度的变化和生理功能;通过比较中药药性中的四气理论、五味理论(辛味)和不同TRPs家族通道对温度敏感差异的特性,分析四气理论中寒、凉、温、热和辛味药性与TRPs家族之间生理功能的关系,提出中药药性与现代生物医学研究结合的可能性。
The family ion channel-related receptors of transient receptor potentials(TRPs) in mammalian are widely distributed in the human body,which are involved in the regulation of basic metabolism and serve as potential therapeutic targets for the cardiovascular system,nervous system,and tumor diseases.This paper described the changes in temperature-sensing and physiological functions of different family ion channels of TRPs.By comparing the characteristics of the four property theory,the five taste theory(pungent),and the difference in different family channels of TRPs sensitive to temperature,the relationship between the cold,cool,warm,and hot in the four property theory,pungent taste,and the physiological function of the family of TRPs was analyzed,and the possibility of combining the traditional Chinese medicine properties with modern biomedical research was put forward.