文献类型：期刊文献

英文题名：The gut homeostasis-immune system axis: novel insights into rheumatoid arthritis pathogenesis and treatment

作者：Qi, Peng[1];Chen, Xin[2];Tian, Jiexiang[2];Zhong, Kexin[1];Qi, Zhonghua[1];Li, Menghan[1];Xie, Xingwen[1,2]

第一作者：Qi, Peng

通信作者：Xie, XW[1];Xie, XW[2]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85206021346);WOS:【SCI-EXPANDED(收录号:WOS:001328994100001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by the National Nature Fund Regional Project (82160911, 81860864). Central University Basic Scientific Research Business Expenses Project (31920210041). The special project of science and technology development under the guidance of the central government (YDZX20206200002356).

语种：英文

外文关键词：gut homeostasis; immune system; rheumatoid arthritis; pathogenesis; novel therapeutic approaches

摘要：Rheumatoid arthritis is a widely prevalent autoimmune bone disease that imposes a significant burden on global healthcare systems due to its increasing incidence. In recent years, attention has focused on the interaction between gut homeostasis and the immune system, particularly in relation to bone health. Dysbiosis, which refers to an imbalance in the composition and function of the gut microbiota, has been shown to drive immune dysregulation through mechanisms such as the release of pro-inflammatory metabolites, increased gut permeability, and impaired regulatory T cell function. These factors collectively contribute to immune system imbalance, promoting the onset and progression of Rheumatoid arthritis. Dysbiosis induces both local and systemic inflammatory responses, activating key pro-inflammatory cytokines such as tumor necrosis factor-alpha, Interleukin-6, and Interleukin-17, which exacerbate joint inflammation and damage. Investigating the complex interactions between gut homeostasis and immune regulation in the context of Rheumatoid arthritis pathogenesis holds promise for identifying new therapeutic targets, revealing novel mechanisms of disease progression, and offering innovative strategies for clinical treatment.