文献类型：期刊文献

中文题名：富血小板血浆治疗早期股骨头坏死的研究进展

英文题名：Research progress on treatment of early femoral head necrosis with platelet rich plasma

作者：王静[1];赵乐[1];曾健康[1];李培杰[1];谭飞[1];李嘉欢[1];乔永杰[2];周胜虎[2]

第一作者：王静

机构：[1]甘肃中医药大学,兰州730030;[2]兰州解放军联勤保障部队第九四〇医院,730050

第一机构：甘肃中医药大学

年份：2024

卷号：18

期号：6

起止页码：773

中文期刊名：中华关节外科杂志(电子版)

外文期刊名：Chinese Journal of Joint Surgery(Electronic Edition)

收录：CSCD:【CSCD2023_2024】；

基金：甘肃省重点研发计划(21YF5FA154);甘肃省青年科技基金(20JR5RA588)

语种：中文

中文关键词：股骨头坏死;富血小板血浆;胞间信号肽类和蛋白质类;综述

外文关键词：Femoral head necrosis;Platelet rich plasma;Intercellular signaling peptides and proteins;Review

摘要：股骨头坏死是骨科常见且治疗困难的髋关节疾病,主要临床表现为跛行、髋关节屈伸活动受限及髋部疼痛。如不及时治疗一旦引起股骨头塌陷或继发骨关节炎,最终需行全髋关节置换术。目前临床上治疗股骨头坏死主要根据国际骨循环学会(ARCO)分期选择不同的治疗方式。针对早期患者通常采取“保髋”治疗,常用术式有髓心减压、自体骨移植、干细胞治疗等;而对于晚期患者则多采取全髋关节置换术。但是,防治塌陷一直是治疗股骨头坏死的关键节点。近年来,富血小板血浆(PRP)在促进股骨头软骨修复及血管再生等方面具有较好效果。因此,本文对PRP治疗股骨头坏死的机制及其临床应用进行归纳整理,以期对后续研究提供参考和方向。
Necrosis of the femoral head is a common and difficult-to-treat hip disease in orthopedics,with the main clinical manifestations of claudication,limitation of hip flexion and extension activities,and hip pain.If left untreated once the femoral head collapses or secondary osteoarthritis occurs,total hip replacement is eventually required.Currently,the clinical treatment of femoral head necrosis is mainly based on Association Research Circulation Osseous(ARCO)staging to choose different treatment modalities.Early-stage patients are usually treated with"hip preservation",and the commonly used surgical methods include medullary decompression,autologous bone grafting,stem cell therapy,etc.,while total hip arthroplasty is often used for advanced patients.However,prevention of collapse has always been the key point in the treatment of femoral head necrosis.In recent years,platelet-rich plasma(PRP)has been effective in promoting cartilage repair and vascular regeneration of the femoral head.Therefore,this paper summarized the mechanism of PRP in the treatment of femoral head necrosis and its clinical application,with a view to providing reference and direction for subsequent research.