文献类型：期刊文献

中文题名：养颜祛斑颗粒抗D-半乳糖所致小鼠皮肤衰老作用

英文题名：Experimental Study of Anti-aging Effect of Yangyan Quban Particles on Aging Model Mice’s Skin Caused by D-galactose

作者：王倩[1];高慧琴[1]

第一作者：王倩

机构：[1]甘肃中医学院

第一机构：甘肃中医药大学

年份：2008

卷号：15

期号：5

起止页码：23

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

基金：甘肃省教育厅科学研究基金(GS999-05)

语种：中文

中文关键词：养颜祛斑颗粒;皮肤衰老;D-半乳糖;小鼠

外文关键词：Yangyan Quban particles; skin aging; D-galactose： mice

摘要：目的探讨内服养颜祛斑颗粒抗皮肤衰老作用及机制。方法昆明种雌性小鼠每日背部皮下注射D-半乳糖1000mg/(kg·d)造成小鼠衰老模型,同时按高、中、低剂量(6.68、3.34、1.67g/kg)分别灌服养颜祛斑颗粒,42d后测定小鼠背部皮肤组织匀浆中谷胱甘肽过氧化物酶(GSH-Px)活性及血清中雌二醇(E2)的含量,并考察对小鼠子宫、卵巢、皮肤干重、湿重及水摄取量的影响。结果与衰老模型组比较,养颜祛斑颗粒给药组小鼠皮肤中GSH-Px活力及E2含量明显升高,尤以中剂量为最佳(P<0.05,P<0.01),而对小鼠子宫、卵巢、皮肤干重、湿重及水摄取量有增加趋势。结论养颜祛斑颗粒对D-半乳糖所致衰老小鼠皮肤有明显的抗衰老作用。
Objective To investigate the mechanism of anti-aging effect of Yangyan Quban particles on the aging skin. Methods With the dose of D-galactose 1000 mg/（kg · d） by sc administration to the female mice for 42 days, the aging model was established. The mice received Yangyan Quban particles （6.68, 3.34, 1.67 g/kg） by ig administration at the same time of injecting D-galactose. Forty-two days later, the dorsal skin samples were collected to determine glutathione peroxidase （GSH-Px） activity and serum estradiol （E2） contents, and the influence on uterus, ovary, skin dry and wet weight and the amount of water intake were studied. Results Compared with the aged model mice, the GSH-Px activity and E2 contents in the mice treated with Yangyan Quban particles were increased remarkably, especially the medium is the best dose （P〈0.05, P〈0.01）, while the uterus, ovary, skin dry and wet weight and intake of water had the increase tendency. Conclusion Yangyan Quban particles has obvious anti-aging effects on aging mice＇s skin.