文献类型：期刊文献

中文题名：中医药调控细胞自噬治疗慢性阻塞性肺疾病研究进展

英文题名：Research Progress on the Regulation of Autophagy by Traditional Chinese Medicine in the Treatment of Chronic Obstructive Pulmonary Disease

作者：武金伟[1];张毅[1,2];蒋倩羽[1];张悦[1];郝彬彬[1];把得婷[1]

第一作者：武金伟

机构：[1]甘肃中医药大学,甘肃兰州730101;[2]甘肃中医药大学第四附属医院,甘肃兰州730060

第一机构：甘肃中医药大学

年份：2024

卷号：41

期号：5

起止页码：76

中文期刊名：中医药信息

外文期刊名：Information on Traditional Chinese Medicine

基金：甘肃省自然科学基金项目(21JR11RA142);甘肃省高等学校创新能力提升项目(2019A-075)。

语种：中文

中文关键词：慢性阻塞性肺疾病;细胞自噬;中医药;研究进展

外文关键词：Chronic obstructive pulmonary disease(COPD);Autophagy;Traditional Chinese medicine;Research progress

摘要：慢性阻塞性肺疾病(COPD)是呼吸系统的常见病及多发病,发病率高且难以治愈。细胞自噬在COPD中具有双重作用,与COPD发病机制关系密切。中医药治疗COPD具有疗效显著、不良反应少等特点,并可以双向调节细胞自噬相关靶点。本文对中医药影响细胞自噬干预COPD的具体分子机制进行了归纳总结,发现其作用主要体现在促进细胞自噬、抑制细胞自噬两个方面。一方面,中医药可通过发挥对细胞自噬的促进作用,加速对炎性蛋白聚集体的清除,下调促炎细胞因子的释放,降低炎症反应;另一方面,中医药通过发挥对细胞自噬的抑制作用,减轻气道炎症,抑制细胞凋亡,减少肺组织损伤。
Chronic obstructive pulmonary disease(COPD)is a common and frequently-occurring respiratory disease with high incidence and difficult to cure.Autophagy has a dual role in COPD and is closely related to the pathogenesis of COPD.Traditional Chinese medicine(TCM)in the treatment of COPD has the characteristics of significant efficacy,less adverse reactions,and bidirectional regulation of autophagy related targets.In this paper,the specific molecular mechanism of TCM's influence on autophagy in COPD was summarized,and it was found that its function was mainly embodied in promoting and inhibiting autophagy of cells.On the one hand,TCM can promote autophagy,accelerate the clearance of inflammatory protein aggregates,down-regulate the release of pro-inflammatory cytokines,and reduce inflammatory response.On the other hand,by exerting its inhibitory effect on autophagy,TCM can reduce airway inflammation,inhibit cell apoptosis,and reduce lung tissue damage.