文献类型：期刊文献

英文题名：A novel fluorescent probe with high sensitivity for sequential detection of CN^- and Al³⁺ in highly aqueous medium and its applications in living cell bioimaging

作者：Xie, Yong-Qiang[1];Han, Ming-Ming[1];Zhang, You-Ming[2,3];Chen, Hui[1];Zhang, Hao-Bo[1];Ren, Chun-Yan[1];Li, Lin[1];Wu, Rong[1];Yao, Hong[2];Shi, Xiao-Ning[1];Lin, Qi[2];Wei, Tai-Bao[2]

第一作者：谢永强

通信作者：Shi, XN[1];Zhang, YM[2];Lin, Q[2];Wei, TB[2];Zhang, YM[3]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Expt & Training Teaching Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Eco Environm Polymer Mat Gansu Prov, Key Lab Eco Funct Polymer Mat,Minist Educ, Lanzhou 730070, Gansu, Peoples R China;[3]Gansu Nat Energy Res Inst, Lanzhou 730046, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Expt & Training Teaching Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Eco Environm Polymer Mat Gansu Prov, Key Lab Eco Funct Polymer Mat,Minist Educ, Lanzhou 730070, Gansu, Peoples R China;[3]corresponding author), Gansu Nat Energy Res Inst, Lanzhou 730046, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2023

卷号：437

外文期刊名：JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001008667300001)】；

基金：The work was completed with the support of the Higher Education Innovative Foundation of Gansu Province (No. 2020A-077, 2022A-066) , the National Natural Science Foundation of China (No. 21661028, 21662031, 22165027 and 21574104) , the Youth Foundation of Gansu University of Chinese Medicine (ZQ2017-10) , the Natural Science Foundation of Gansu Province (20JR10RA328) .

语种：英文

外文关键词：Sequential detection; Multipath analysis; CN-; Cell imaging; Density functional theory; Al3+

摘要：Benzothiazole refers to a type of heteroaromatic compound constituted by electron rich nitrogen and sulphur atoms from molecular level, and presents powerful fluorescence in solutions, resulting its widely application in fluorescent whitening agents, fluorescent dyes and functional coordination. In this paper, we focused on designing and synthesizing a benzothiazole-functionalized naphthalimide fluorescent probe NIB for sequentially detecting CN- and Al3+ in DMSO/H2O (1:9, v/v) solution using these fluorescence properties of benzothiazole. When the fluorescent probe NIB interacts with CN-, the fluorescence of the probe is quenched, indicating that NIB can specifically respond to CN-. According to the anti-interference experiment, NIB possesses strong antiinterference ability toward CN-, and its detection limit of CN- is 6.31 x 10-7 M. Interestingly, the fluorescence of the NIB-CN- system was turned back on again by adding Al3+ ions which has good anti-interference performance against other cations. The lowest detection limit of NIB-CN- system for Al3+ is 2.85 x 10-6 M. After 10 cycles, NIB still has good sequential detection performance for CN- and Al3+, which can serve as a highly sensitive logic gate for the detection of CN- and Al3+, and the "On-Off-On" switches of this fluorescence can be observed under UV light megascopically. The mechanism of sequential detection of CN- and Al3+ was further discussed by experimental and theoretical methods. The detection mechanism is not the traditional coordination competition mechanism, but the sequential addition of CN- and Al3+ changes the aggregation mode of probe molecules in the system. In addition, the potential application of this probe was fully confirmed by the preparation of probe NIB test paper and the realization of sequential detection of CN- and Al3+ in living cells (HeLa).