文献类型：期刊文献

中文题名：中药单体改善肾缺血再灌注损伤的分子机制研究进展

英文题名：Research progress on the molecular mechanisms of traditional Chinese medicine monomers in ameliorating renal ischemia-reperfusion injury

作者：黄锦蕊[1];刘伟[1];魏锦慧[2];常育博[1];马鸿斌[2]

第一作者：黄锦蕊

机构：[1]甘肃中医药大学研究生院,兰州730000;[2]甘肃中医药大学附属医院肾病科,兰州730030

第一机构：甘肃中医药大学党委研究生工作部、研究生院

年份：2026

卷号：37

期号：4

起止页码：540

中文期刊名：中国药房

外文期刊名：China Pharmacy

收录：;北大核心:【北大核心2023】；

基金：甘肃省自然科学基金项目(No.23JRRA1193);甘肃省名中医传承工作室建设项目(No.甘财社[2022]105号);兰州市科技计划项目(No.2022-5-111)。

语种：中文

中文关键词：肾缺血再灌注损伤;中药单体;通路;氧化应激;急性肾损伤

外文关键词：renal ischemia-reperfusion injury;traditional Chinese medicine monomers;pathway;oxidative stress;acute kidney injury

摘要：肾缺血再灌注损伤(RIRI)是肾移植及围手术期急性肾损伤的重要病因,临床尚缺乏安全有效的靶向防治药物。黄腐酚、木犀草素、龙血素C、柚皮素、洋川芎内酯Ⅰ、毛蕊花糖苷、紫草素等通过核转录因子红系2相关因子2/血红素加氧酶1增强抗氧化防御、抑制脂质过氧化与铁死亡;芹菜素、川陈皮素、丹参酮ⅡA、红景天苷等激活磷脂酰肌醇3-激酶/蛋白激酶B通路抑制线粒体途径凋亡并促进修复;槲皮素、甲基丁香酚、矢车菊素-3-葡萄糖苷、桔梗皂苷D等通过腺苷一磷酸活化蛋白激酶(AMPK)/哺乳动物雷帕霉素靶蛋白或AMPK/磷酸酶及张力蛋白同源物诱导激酶1/帕金蛋白促进自噬,改善线粒体稳态;橙皮苷、姜黄素、灵芝酸、白头翁皂苷B4、辣椒素、薯蓣皂苷等通过抑制Toll样受体4/核因子κB、高迁移率族蛋白B1、Janus激酶/信号转导及转录激活因子等炎症通路,降低促炎性细胞因子释放与肾小管损伤指标,从而实现多靶点、多环节的肾保护作用。
Renal ischemia-reperfusion injury(RIRI)is a major cause of acute kidney injury during kidney transplantation and peri-operative settings,and there is still a lack of safe and effective targeted preventive and therapeutic drugs in clinical practice.Specifically,xanthohumol,luteolin,dracorhodin C,naringin,senkyunolideⅠ,verbascoside,and shikonin enhance antioxidant defenses,and inhibit lipid peroxidation and ferroptosis via the nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 pathway.Apigenin,nobiletin,tanshinoneⅡA,and salidroside activate the phosphatidylinositol 3-kinase/protein kinase B pathway to inhibit mitochondria-dependent apoptosis and facilitate renal repair.Quercetin,methyleugenol,cyanidin-3-glucoside,and platycodin D promote autophagy and improve mitochondrial homeostasis through the adenosine monophosphate-activated protein kinase(AMPK)/mTOR or AMPK/phosphatase and tensin homolog-induced kinase 1/Parkin pathways.In addition,hesperidin,curcumin,ganoderic acid,pulsatilla saponin B4,capsaicin,and diosgenin mitigate inflammatory responses and decrease renal tubular injury markers by inhibiting the Toll-like receptor 4/nuclear factorκB,high mobility group box 1,Janus kinase/signal transducer and activator of transcription pathways,thereby exerting multi-target,multi-stage renoprotective effects.