文献类型：期刊文献

中文题名：胃癌组织中CEACAM6、MMP-9的表达及其与临床病理的关系

英文题名：Expressions of CEACAM6 and MMP-9 in gastric carcinoma and their relationship with clinicopathological features:report of 54 cases

作者：潘海邦[1,2];王波[2];杨爱军[3];关泉林[1]

第一作者：潘海邦

机构：[1]兰州大学第一医院肿瘤外科,兰州730000;[2]甘肃中医学院临床医学系,兰州730000;[3]兰州大学病理教研室,兰州730000

第一机构：兰州大学第一医院肿瘤外科,兰州730000

年份：2010

卷号：32

期号：24

起止页码：2632

中文期刊名：第三军医大学学报

外文期刊名：Journal of Third Military Medical University

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：胃癌;CEACAM6;MMP-9;微血管密度;免疫组化

外文关键词：gastric cancer; CEACAM6; MMP-9; microvessel density; immunohistochemistry

摘要：目的探讨CEACAM6、MMP-9在胃癌组织中的表达及其与微血管生成之间的关系。方法免疫组化法分别检测CEACAM6、MMP-9在54例胃癌组织及10例胃正常组织中的表达情况及与微血管密度(microvessel density,MVD)表达的相关性。结果 CEACAM6、MMP-9在胃癌组织中表达率分别为85.19%(46/54)、74.7%(40/54),明显高于胃正常组织中表达率30%(3/10)、20%(2/10),胃癌组织中MVD值(32.17±8.97)明显高于胃正常组织[(18.62±5.07),P<0.05)]。胃癌组织中CEACAM6与性别、年龄、分化程度和淋巴结转移无关(P>0.05);而与浸润深度、临床分期有关(P<0.05)。MMP-9和MVD与性别、年龄无关(P>0.05);而与浸润深度、临床分期、分化程度及淋巴结转移有关(P<0.05);CEACAM6与MMP-9在胃癌组织中的表达呈正相关(r=0.593,P=0.000);CEACAM6、MMP-9阳性表达的MVD明显高于相应阴性表达(P<0.05)。结论 CEACAM6、MMP-9在胃癌组织中高表达,可能参与了胃癌的发生、发展,与胃癌微血管生成和浸润、转移有关。
Objective To investigate the expressions of CEACAM6（CD66c） and MMP-9 in gastric cancer tissue and their relationship with tumor micro-angiogenesis.Methods Immunohistochemistry was used to detect the expressions of CEACAM6 and MMP-9,and microvessel density（MVD） in 54 samples of gastric cancer and 10 normal gastric tissue.The clinical data were retrospectively analyzed.Results The positive rates of CEACAM6 and MMP-9 in gastric carcinoma tissue were 85.19%（46/54） and 74.7%（40/54）,respectively,which were significantly higher than those in normal gastric tissue [30.00%（3/10）,20.00%（2/10）,respectively,P0.05].The value of MVD in gastric cancer tissue was 32.17±8.97,which was significantly higher than that in normal gastric tissue（18.62±5.07,P0.05）.The expression of CEACAM6 was associated significantly with depth of invasion and clinical stage of gastric cancer（P0.05）,but was not associated with gender,age,differentiation and lymph node metastasis（P0.05）.The expression of MMP-9 and the value of MVD were associated significantly with depth of invasion,clinical stage,differentiation and lymph node metastasis of gastric cancer（P0.05）,but they had no relation with gender and age（P0.05）.There was a significantly positive correlation between CEACAM6 expression and MMP-9 expression in gastric cancer tissue（r=0.593,P=0.000）.The value of MVD in the individuals with positive expression of CEACAM6 or MMP-9 was significantly higher than that in the patients negative to CEACAM6 or MMP-9（P0.05）.Conclusion Moderate and strong expressions of MMP-9 and CEACAM6 in gastric cancer tissue are associated with tumor micro-angiogenesis,invasion and metastasis,which may contribute to the occurrence and development of gastric cancer.