文献类型：期刊文献

中文题名：肝纤胶囊对急慢性肝损伤的影响

英文题名：Effects of Ganxian capsule (肝纤胶囊) on the acute and chronic liver injury

作者：马骏[1];夏仁福[1];朱书强[1];张惠珍[2];王维[2];李小红[2];谢军国[2];董永军[2]

第一作者：马骏

机构：[1]甘肃中医学院,兰州730000;[2]甘肃省庆阳市中医医院,庆阳745000

第一机构：甘肃中医药大学

年份：2008

卷号：24

期号：2

起止页码：70

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

基金：甘肃省中医药科研课题(2004-GZK-08)

语种：中文

中文关键词：肝纤胶囊;肝损伤;肝纤维化

外文关键词：Ganxian capsules（肝纤胶囊） ; liver injury; liver fibrosis

摘要：目的:研究肝纤胶囊对急慢性肝损伤的保护作用。方法:采用四氯化碳(CCl4)和D-氨基半乳糖盐酸盐(D-GalN)复制小鼠急性肝损伤模型,观察该药对血清丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)的影响,以及对组织病理学变化的影响;采用CCl4及高脂饲料等复合因素复制大鼠慢性肝纤维化模型,观察该药对肝组织羟脯氨酸含量的影响,以及对组织病理学变化的影响。结果:与模型对照组比较,肝纤胶囊能明显降低血清ALT和AST,能明显降低肝组织羟脯氨酸含量,改善组织病理学变化。结论:肝纤胶囊对急慢性肝损伤具有保肝降酶、抗肝纤维化的作用。
Objective： To observe the effect of Ganxian capsule on experimental liver injury and liver fibrosis. Methods： The actue liver injury model was established in mice by CC14 and D-GaiN. The chronic liver fibrosis model was established in rats by CC14 and other composite of factors. The serum aminotransferase （ ALT, AST） in mice and liver tissue contents of hydroxyproline in rats were measured, histologic changes of liver tissue were observed at the end of the experiment. Results ： The experimental results showed that Ganxian capsule had remarkable protective effects against the actue and chronic liver damage, inhibited the increase of serum ALT and AST in mice, decreased liver hydroxyproline level in rats. Histological lesion of liver in Ganxian capsules gruop were less severe than those of hepatic injury control. Conclusion： It suggested that Ganxian capsule has effects of protecting liver and anti-liver fibrosis.