文献类型：期刊文献

中文题名：胡蓝骨架缓释片成型工艺研究

英文题名：Study of Forming Process for Hulan Sustained-Release Tablets

作者：王晓莉[1];李季文[2];景明[3];刘效栓[2];李喜香[2]

第一作者：王晓莉

机构：[1]甘肃中医学院附属医院,甘肃兰州730000;[2]甘肃省中医院,甘肃兰州730050;[3]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2012

卷号：19

期号：5

起止页码：51

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

基金：甘肃省科技支撑计划(090NKCA103)

语种：中文

中文关键词：胡芦巴;绞股蓝;骨架;缓释片;药物释放度

外文关键词：Trigonellae Semen; Gynostemma Pentaphyllum; frame; sustained-release tablets; drug release rate

摘要：目的以羟丙基甲基纤维素(HPMC)为骨架材料,制备胡蓝降糖缓释片,并考查其体外释放度。方法以单因素试验法考察骨架材料型号、用量及润滑剂对体外释放的影响,优化处方工艺。结果随骨架材料用量的增加,胡蓝降糖缓释片的缓释作用加强。结论胡蓝降糖缓释片制备工艺简单易行,具有明显的缓释作用。
Objective With HPMC as frame material,to made Hulan hypoglycemic sustained-release tablets,and investigate its release rate in vitro.Methods The process was optimized by investigating the impact of skeleton material type,dosage and lubricant on release rate in vitro with sigle factor experiment.Results With the increase of the skeleton material dosage,the sustained-release effect of Hulan hypoglycemic sustained-release tablets was enhanced.Conclusion The process of Hulan hypoglycemic sustained-release tablets was simple and feasible,and has obvious sustained-release effect.