文献类型：期刊文献

英文题名：Identification of Drosophila melanogaster as a model organism in COPD research

作者：Zhang, Yuan[1,2,3,4];Kou, Jing[5];Zhang, Yuxuan[5];Huang, Haiyi[5];Yang, Yang[5];Liu, Chengshuang[5];Lu, Ting[6];Zhao, Xiaoxuan[6];Liu, Yongqi[1,2,3,4];He, Jianzheng[1,2,3,4]

第一作者：张媛;张元

通信作者：Liu, YQ[1];He, JZ[1];Liu, YQ[2];He, JZ[2];Liu, YQ[3];He, JZ[3];Liu, YQ[4];He, JZ[4]

机构：[1]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial L, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Coll Integrat Med, Lanzhou, Peoples R China;[6]Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Lanzhou, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial L, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105031057993);WOS:【SCI-EXPANDED(收录号:WOS:001699194800001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the National Natural Science Foundation of China (Nos. U23A20502 and 82104562), Foundation from Key Laboratory of Dunhuang Medicine, Ministry of Education (No. DHYX23-11), and Lanzhou Science and Technology Plan Project (No. 2022-5-77).

语种：英文

外文关键词：COPD models; COPD pathogenesis; Drosophila melanogaster; genetic characteristics; therapies

摘要：Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterized by increasing mortality and morbidity. Current animal models have certain limitations in elucidating the pathophysiology and underlying mechanisms of COPD, which hinder effective treatments. There is an urgent need to identify an informative model that can dissect the COPD mechanisms and screen therapeutic drugs. The Drosophila melanogaster is regarded as an ideal in vivo model for studying COPD due to its ability to present representative pathological hallmarks within a short time frame, its visualized tracheal morphology, and well-established genetic tools. In this study, we explore the feasibility of using Drosophila as a novel invertebrate model for investigating COPD. We summarize the conserved features between flies and mammals in response to airway inflammation, including airway structures, pathophysiological changes, immune responses, molecular mechanisms, and modeling approaches. Additionally, we outline potential translational applications, including high-throughput identification, drug discovery, and a prioritized preclinical platform. We also propose integrating insights from Drosophila with mammalian models and clinical COPD endotypes.