文献类型：期刊文献

中文题名：Notch信号通路在类风湿关节炎病理机制中的研究现状

英文题名：Research status of the Notch signaling pathway in the pathogenesis of rheumatoid arthritis

作者：漆文霞[1];王嘉[1];贺童[1];田杰祥[2];王涛[2];闫彦峰[3];张媛媛[2];王钢[2]

第一作者：漆文霞

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学附属医院风湿骨病科,甘肃兰州730020;[3]甘肃中医药大学第四附属医院呼吸与危重症医学科,甘肃兰州730060

第一机构：甘肃中医药大学中西医结合学院

年份：2025

卷号：41

期号：3

起止页码：438

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(81860858、81960832);甘肃省科技基金资助项目(22JR11RA131)。

语种：中文

中文关键词：类风湿关节炎;Notch信号通路;虚毒瘀;中西医结合

外文关键词：rheumatoid arthritis;Notch signal path;Xu,Du and Yu;combination of Chinese and Western medicine

摘要：类风湿关节炎(RA)在中医学属归属于“痹证”“历节病”等范畴,肝肾不足,髓不能养骨,感受外邪,长期郁结于体内,化热成毒,损及气血经络,热毒痰浊瘀血痹阻而发病,虚实夹杂,缠绵难愈。Notch信号通路与本病具有较大的相关性,其参与了炎性细胞浸润、成纤维样滑膜细胞的增殖、微血管的形成及骨质破坏等多种病理过程。本文从中西医结合的角度,基于中医虚、毒、瘀的病机理论,深入探讨Notch信号通路与本病的相关性,以期为研究提供新思路。
Rheumatoid arthritis(RA)is categorized as"bi zheng"and"li-jiebing"in Chinese medicine.Liver and kidney insufficiency,marrow can not nourish the bones,feel the external evil,long-term accumulation in the body,heat into poison,damage to the qi and blood meridians and collaterals,heat and poison,phlegm,blood stasis and paralysis and the onset of the disease,mixed with the real and the imaginary,difficult to be cured.The Notch signaling pathway has a greater relevance to this disease,and it is involved in various pathological processes such as inflammatory cell infiltration,proliferation of fibroblast-like synoviocytes(FLS),microvascular formation and bone destruction.In this paper,the correlation between Notch signaling pathway and this disease is discussed from the perspective of the combination of Chinese and Western medicine,based on the theory of"XU,DU,YU"of traditional Chinese medicine,with the aim of providing a new way of thinking for the research.