文献类型：期刊文献

英文题名：MEX3A: A promising prognostic marker and therapeutic target in hepatocellular carcinoma

作者：Yang, Xin-Le[1];Yang, Xiao-Jun[2]

第一作者：杨相霖;杨晓兰;杨小玲;杨晓莉;杨小龙;杨晓玲

通信作者：Yang, XJ[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Sch 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Peoples Hosp, Dept Gen Surg, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Gen Surg, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2025

卷号：17

期号：10

外文期刊名：WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001596673500032)】；

语种：英文

外文关键词：MEX3A; Hepatocellular carcinoma; Immune microenvironment; Cancer stem cells; Immunotherapy; Organoids

摘要：This article discusses the recently published study by Ji et al on the role of MEX3A in hepatocellular carcinoma. The study reveals MEX3A's role, but has issues including a small sample size and unclear RORA-regulation. We propose new research directions. It is essential to analyze the immune cells in MEX3A-high tumors and test the impact of MEX3A-knockout on immunotherapy when exploring the relationship between MEX3A and the immune microenvironment. With regard to MEX3A and cancer stem cells, it is necessary to assess the effect of MEX3A on cancer stem cell self-renewal and use organoids to test the targeting ability of MEX3A-inhibitors. In addition, improvements such as larger-scale validation and in-depth mechanism research are required, which could boost hepatocellular carcinoma understanding and patient prognosis.