文献类型：期刊文献

英文题名：Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non-alcoholic fatty liver disease via adenosine monophosphate-activated protein kinase pathway activation

作者：Sun, Wei-Ming[1,2];Wang, Yu-Ping[3,4];Duan, Yong-Qiang[1,5];Shang, Hong-Xia[5];Cheng, Wei-Dong[1,6]

第一作者：Sun, Wei-Ming

通信作者：Cheng, WD[1]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Hosp 1, Dept Endocrinol, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Hosp 1, Dept Gastroenterol, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Coll Tradit Chinese Med, Dept Basic Courses, Lanzhou 730000, Gansu, Peoples R China;[6]Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, 199 Dong Gang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2014

卷号：10

期号：3

起止页码：1237

外文期刊名：MOLECULAR MEDICINE REPORTS

收录：;Scopus(收录号：2-s2.0-84905455008);WOS:【SCI-EXPANDED(收录号:WOS:000340854500008)】；

基金：This study was supported by the Fundamental Research Funds for the Central Universities (grant no. lzujbky-2013-159) and the Scientific Research Project of Traditional Chinese Medicine Administration in Gansu Province (grant no. GZK-2012-65). The authors would like to thank Xiao-Liang Jin for assistance in the animal experiments.

语种：英文

外文关键词：Radix Hedysari; polysaccharide; lipid metabolism; non-alcoholic fatty liver disease; adenosine monophosphate-activated protein kinase pathway

摘要：Oxidative stress and excess hepatic lipid accumulation contribute to non-alcoholic fatty liver disease. Radix Hedysari polysaccharides (RHP) have attracted interest due to their antioxidant properties and immunomodulatory effects. However, the effect of RHP on hepatic lipid metabolism remains to be elucidated. In the present study, the response of Sprague-Dawley rat livers to a high-fat diet and RHP treatment was investigated by evaluating body weight, liver histology, hepatic lipid content, adenosine monophosphate-activated protein kinase (AMPK) activity and lipid metabolism gene transcriptional profiles. The present study demonstrated that RHP ameliorated lipid metabolism disorders, regulated hepatic lipid content, improved liver inflammation and damage, activated AMPK via phosphorylation, upregulated peroxisome proliferator-activated receptor a and downregulated the mRNA expression of sterol regulatory element binding protein-lc in rat livers, which reduced lipogenesis and increased lipolysis. Taken together, these results suggested that RHP effectively ameliorates lipid metabolism disorders in rat livers; thus, RHP may be a potential therapeutic agent in the prevention of hepatic steatosis