文献类型：期刊文献

英文题名：Crocetin: A Systematic Review

作者：Guo, Zi-Liang[1,2];Li, Mao-Xing[1,2,3];Li, Xiao-Lin[1];Wang, Peng[1,3];Wang, Wei-Gang[1,3];Du, Wei-Ze[1,3];Yang, Zhi-Qiang[1,4];Chen, Sheng-Fu[1,3];Wu, Di[1,5];Tian, Xiu-Yu[1,2]

第一作者：Guo, Zi-Liang

通信作者：Li, MX[1];Li, MX[2];Li, MX[3]

机构：[1]Chinese PLA, Gansu Plateau Pharmaceut Technol Ctr, Dept Clin Pharm, Hosp 940,Joint Logist Support Force, Lanzhou, Peoples R China;[2]Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[4]Northwest Minzu Univ, Inst Chem Technol, Lanzhou, Peoples R China;[5]Ningxia Med Univ, Coll Pharm, Yinchuan, Ningxia, Peoples R China

第一机构：Chinese PLA, Gansu Plateau Pharmaceut Technol Ctr, Dept Clin Pharm, Hosp 940,Joint Logist Support Force, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Chinese PLA, Gansu Plateau Pharmaceut Technol Ctr, Dept Clin Pharm, Hosp 940,Joint Logist Support Force, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2022

卷号：12

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85123703349);WOS:【SCI-EXPANDED(收录号:WOS:000748178900001)】；

基金：This work was supported by the project of the Fundamental Research Funds for the Central Universities (31920200010), the major research and development program of Gansu Province (20YF3FA035), the Emergency Medical Research Project of Novel Coronavirus Pneumonia (COVID-19) (20yjky018), Scientific Research Program of Health Industry in Gansu Province (GSWSKY 2020-41), Top-notch cultivation project (2021yxky001), Youth development program (2021yxky060). Logistics Research Project (CLB21J036).

语种：英文

外文关键词：crocetin; crocetin derivatives; distribution; pharmacological activity; pharmacokinetics; toxicity; formulation

摘要：Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological systems by hydrolysis of crocin as a bioactive metabolite. It is known to exist in several medicinal plants, the desiccative ripe fruit of the cape jasmine belonging to the Rubiaceae family, and stigmas of the saffron plant of the Iridaceae family. According to modern pharmacological investigations, crocetin possesses cardioprotective, hepatoprotective, neuroprotective, antidepressant, antiviral, anticancer, atherosclerotic, antidiabetic, and memory-enhancing properties. Although poor bioavailability hinders therapeutic applications, derivatization and formulation preparation technologies have broadened the application prospects for crocetin. To promote the research and development of crocetin, we summarized the distribution, preparation and production, total synthesis and derivatization technology, pharmacological activity, pharmacokinetics, drug safety, drug formulations, and preparation of crocetin.