文献类型：期刊文献

中文题名：踝舒对急性软组织损伤PGE_2影响的实验研究

英文题名：THE INFLUENCE OF "HUAISHU" ON PCE2 IN ANIMAL MODELS OF ACUTE SOFT-TISSUE INJURY: An Experimental Study

作者：邱桐[1];朱换平[1];练维娟[1];许晓英[1]

第一作者：邱桐

机构：[1]甘肃中医学院

第一机构：甘肃中医药大学

年份：2004

卷号：16

期号：1

起止页码：15

中文期刊名：中医正骨

外文期刊名：The Journal of Traditional Chinese Orthopedics and Traumatology

语种：中文

中文关键词：软组织损伤/中医药疗法;踝舒/治疗应用;前列腺素;E2;实验研究;动物;兔

外文关键词：soft-tissue injury/TCM therapy, 'HUAISHU'/therapeutic application, E2, experimental study, animal, rabbit

摘要：通过建立家兔急性软组织损伤模型 ,分别在应用踝舒及对照药正骨水涂布患处治疗后第 2 4、72小时取材并匀浆 ,采用放免法测量匀浆液前列腺素E2 (PGE2 )含量。结果显示 ,踝舒能显著抑制家兔急性软组织损伤后受伤局部PGE2 含量的升高 (P <0 .0 1)。表明踝舒治疗急性软组织损伤的机理之一是抑制受伤局部PGE2 含量升高来发挥其抗炎作用。
Rabbit models of acute soft-tissue injury were made and treated by the external application of 'HUAISHU' (HS, a TCD tincture) and 'ZHENGGU SHUI' (ZS, a TCD liquid as the control). At the 24th and 72nd hours after the treatment, the samples and homogenates were taken and the PGE2 levels in the homogenates were determined by radioimmunoassay, respectively. The results showed that HS could remarkably inhibit the ascendance of PGE2 level in the injured site after acute soft-tissue injury (P < 0.01), suggesting that one of the therapeutic mechanisms of HS for acute soft-tissue injury may be to inhibit the ascendance of PGE2 level in the injured site and by this way HS takes the anti-inflammatory effect.