文献类型：期刊文献

中文题名：中药干预类风湿关节炎Th17/Treg细胞失衡及其相关因子的研究进展

英文题名：Research Progress of Chinese Herbal Intervention on Th17/Treg Cell Imbalance and Related Factors in Rheumatoid Arthritis

作者：杨天宁[1];杨会军[2];金芳梅[2];胡乐乐[2];杨娟娟[1];王爱华[2];苏小军[2];王海东[2]

第一作者：杨天宁

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中医院风湿骨病中心,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：34

期号：4

起止页码：564

中文期刊名：中药新药与临床药理

外文期刊名：Traditional Chinese Drug Research and Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82260880);国家重点研发计划项目(2018YFC1705202,2018YFC1705203);甘肃省中医药项目(GZKP-2021-12,GZKZ-2021-3);兰州市科技指导性计划项目(2020-ZD-32;2022-ZD-73);王海东甘肃省名中医传承工作室建设项目。

语种：中文

中文关键词：中药;有效成分;类风湿关节炎;免疫疾病;免疫细胞;Th17/Treg细胞;炎症因子

外文关键词：traditional Chinese medicine;active components;rheumatoid arthritis;immune disease;immune cells;Th17/Treg cells;inflammatory cytokines

摘要：辅助性T17细胞(Th17)/调节性T细胞(Treg)平衡对维持机体正常免疫功能发挥重要作用,有利于机体的免疫稳态。Th17/Treg细胞失衡影响免疫稳态的细胞因子而导致的免疫紊乱在类风湿关节炎的发病中发挥着重要作用。通过研究Th17/Treg细胞失衡状态及其产生的相关因子是开展类风湿关节炎病理机制及防治药物的相关药理研究的途径之一。近年来,以中药调控Th17/Treg细胞失衡来防治类风湿关节炎研究已开展了大量的研究。该文通过总结中药及其有效成分调控类风湿关节炎Th17/Treg细胞失衡及其相关因子的研究成果,为类风湿关节炎的基础研究、中药新药研发和临床治疗提供借鉴。
The balance of T helper type 17 cell(Th17)/T regulatory cell(Treg) plays a significant role in maintaining normal immune function of the body, and it helps maintain immune homeostasis of the organism.Imbalance of Th17/Treg cell affects cytokines of the immune homeostasis and may cause immune disorders,which plays an important role in the pathogenesis of rheumatoid arthritis. The study of Th17/Treg cell equilibrium state as well as the related factors of rheumatoid arthritis is one of the ways for pathological mechanism of rheumatoid arthritis and related pharmacological studies of preventing drug. In recent years, many studies have been carried out on regulating the balance of Th17/Treg cell with Chinese medicine to prevent and treat rheumatoid arthritis. This paper summarizes research results of Chinese medicine and its effective components for regulating the balance of Th17/Treg cell and its related factors in rheumatoid arthritis. It provides references for basic research of rheumatoid arthritis,development of new Chinese medicine and clinical treatment.