文献类型：期刊文献

英文题名：Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention

作者：Han, Xianfu[1];Lin, Demin[1];Huang, Weiwei[1];Li, Dingpeng[2];Li, Ning[1,3];Xie, Xingwen[3]

第一作者：Han, Xianfu

通信作者：Li, N[1];Li, N[2];Xie, XW[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Second Peoples Hosp Gansu Prov, Dept Orthoped, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Dept Orthoped, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll Chinese Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Orthoped, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN GENETICS

收录：;Scopus(收录号：2-s2.0-85152799296);WOS:【SCI-EXPANDED(收录号:WOS:000969138700001)】；

基金：This study was funded by National Natural Science Foundation of China (No. 82060873).

语种：英文

外文关键词：NLRP3 inflammasome; synovitis; knee osteoarthritis; traditional Chinese medicine; review

摘要：Objective: This paper briefly reviews the structure and function of NLRP3 inflammasomes, signaling pathway, relationship with synovitis in KOA, and intervention of traditional Chinese medicine (TCM) in NLRP3 inflammasomes as a means to improve its therapeutic potential and clinical application. Method: Literatures about NLRP3 inflammasomes and synovitis in KOA were reviewed to analyze and discuss. Result: NLRP3 inflammasome can activate NF-.B mediated signal transduction, which in turn causes the expression of proinflammatory cytokines, initiates the innate immune response, and triggers synovitis in KOA. The TCM monomer/active ingredient, decoction, external ointment, and acupuncture regulating NLRP3 inflammasomes are helpful to alleviate synovitis in KOA. Conclusion: The NLRP3 inflammasome plays a significant role in the pathogenesis of synovitis in KOA, TCM intervention targeting the NLRP3 inflammasome can be a novel approach and therapeutic direction for the treatment of synovitis in KOA.