文献类型：期刊文献

中文题名：增龄对胃中间横带和胃排空的影响

英文题名：Effects of aging on midgastric transverse band and gastric emptying

作者：赵丽[1];刘世雄[2];陈明[3];王晶[2];周芸[2];刘纯[3];严祥[2]

第一作者：赵丽

机构：[1]甘肃中医药大学附属医院超声科,兰州730020;[2]兰州大学第一医院老年科,730000;[3]兰州大学第一医院核医学科,730000

第一机构：甘肃中医药大学第二附属医院

年份：2017

卷号：36

期号：2

起止页码：185

中文期刊名：中华老年医学杂志

外文期刊名：Chinese Journal of Geriatrics

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2017_2018】；

基金：甘肃省自然科学基金（1308RJZA219）;甘肃省胃肠病重点实验室开放课题基金项目（gswcky-2012-004）

语种：中文

中文关键词：年龄因素;胃排空

外文关键词：Age factor; Gastric emptying

摘要：目的探讨年龄增加对胃中间横带（MTB）和胃排空的影响。方法前瞻性研究57例健康志愿者按年龄不同分为青年组、中年组和老年组，进食99m锝-亚锡喷替酸（99mTc-DTPA）标记的试餐后利用双探头单光子发射计算体层摄影术（SPECT）采集图像，将胃的每帧影像划分为近端胃、MTB、远端胃，分别测定、计算半排空时间、90min胃内残留率、不同时相胃各部分面积、计数／像素比等。结果青年组、中年组和老年组全胃半排空时间分别为（43．24±11．87）min、（42．07±9．31）min和（45．81±10．73）min，3组间比较差异无统计学意义（P〉0．05）；近端胃半排空时间分别为（38．09±10．26）min、（37．33±9．28）min和（26．74±12．07）min，老年组较青年组、中年组缩短（P〈0．05）；远端胃半排空时间分别为（38．35±12．96）min、（37．73±7．46）min和（46．41±10．74）min，老年组较青年组、中年组延长（P〈0．05）。青年组、中年组和老年组全胃90min胃内核素残留率分别为比较差异无统计学意义；近端胃分别为（25．01±12．35）％、（26．36±15．29）％和（19．54±8．47）％，老年组较青年组、中年组减少（P〈0．05）；远端胃分别为（42．25±12．36）%、（41．56±9．33）％和（56．05±11．72）%，老年组较青年组、中年组增多（P〈0．05）。全胃不同时相面积老年组与青年、中年组比较差异无统计学意义，在30min、60min、90min时相老年组近端胃面积较青年组、中年组减少，远端胃面积较青、中年组增加（P〈0．05），在60min、90min老年组MTB面积较青年组、中年组增大（P〈0．05）。不同时相全胃计数／像素比老年组与青年、中年组间差异无统计学意义，30min、60min和90min时相老年组近端胃计数／像素比较青、中年组减小，而远端胃较青、中年组增大（P〈0．05）；在60min和90min时相老年组MTB计数／像素比较青、中年组增大（P〈0．05）。结论胃排空并未随增龄而减慢，但老年人存在近端胃排空增快而远端胃排空减慢，这种胃内食物分布异常可能与胃中间横带增宽有关。
Objectives To explore the effects of aging on midgastric transverse band（MTB）and gastric emptying. Methods In our prospective study,57 healthy volunteer were divided into young, middle and old-age groups. After taking test meal labeled by 99mTc-diethylenetriaminepentaacetic acid （99mTc-DTPA）, the pictures were collected using double probe single photon emission computed tomography（SPECT）. Stomach in each frame of the pictures was divided into proximal, midgastric transverse band（MTB）and distal parts. And half gastric emptying time, gastric remnant rate at 90 min, areas of different gastric parts were tested and calculated respectively. Results Half gastric emptying time of whole stomach was （43.24 ± 11.87 ） min, （ 42.07 ± 9.31 ） min and （ 45.81 ± 10.73 ） min in young, middle and old-age groups, respectively, with P〈 0.05. Among young, middle and old- age groups, half gastric emptying time was （ 38.09 ± 10.26 ） min, （ 37.33 ± 9.28） min and （ 26.74 ±12.07）min in proximal stomach, and it was （ 38.35 ± 12.96 ） min, （ 37.73 ± 7.46 ） min and （ 46.41 ±10.74）min in distal stomach,respectively. The half gastric emptying time was significantly reduced in proximal stomach and increased in distal stomach in old-age group（both P〈0.05）. The gastric nuclide remnant rate at 90min in total stomach was（30.38±19.32）%,（29.03±10.36）% and（31.92 ±13.47）%,in young, middle and old-age groups, respectively, with P〈0.05. This rate in proximal stomach was（25.01 ± 12.35）%, （26.36± 15.29）%and（19.54± 8.47）% among three group, respectively. The rate in proximal stomach was （ 42.25 ± 12. 36 ） %, （41.56 ± 9.33）% and （56.05 ± 11.72） % among three group,respectively. The gastric remnant rate at 90min was reduced in proximal stomach and was increased in distal stomach significantly in old-age group（both P〈0.05）. Compared with young and middle-age group,the old-age group showed no difference in areas of total stomach in all the time, while the areas were reduced in proximal stomach and increased in distal stomach significantly from 30 min to 90 min（all P〈0.05）. Total stomach versus proximal and distal stomach showed no difference in count/pixel ratio in all time,while a count/pixel ratio was reduced in proximal stomach and increased in distal stomach significantly from 30 min to 90 min（both P〈0.05）. Both areas and count/pixel ratio of MTB at 60 min and 90 min were significantly increased in old-age group（both P〈0.05 ）. Conclusions The total gastric emptying is not delayed along with aging, while the gastric emptying is increased in proximal stomach and reduced in distal stomach in the elderly. This abnormity of intragastric distribution of food might be related with larger area of midgastric transverse band.