文献类型：期刊文献

英文题名：A review of edible plant-derived natural compounds for the therapy of liver fibrosis

作者：Xu, Wenjuan[1,2];Wang, Longde[3];Niu, Yuanyuan[1];Mao, Lanfang[3];Du, Xiaojuan[1];Zhang, Ping[1];Li, Zhengju[1];Li, Hongfang[4];Li, Ning[4]

第一作者：徐文杰

通信作者：Wang, LD[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Prov Hosp Tradit Chinese Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, 732 Jiayuguan West Rd, Lanzhou 730020, Peoples R China;[4]Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, 732 Jiayuguan West Rd, Lanzhou 730020, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：35

期号：2

起止页码：133

外文期刊名：EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

收录：;Scopus(收录号：2-s2.0-85144637046);WOS:【SCI-EXPANDED(收录号:WOS:000904632200001)】；

基金：This work was supported by the National Natural Science Foundation of China (grant numbers 82160883 and 81903430), and the Natural Science Foundation of Gansu Province (grant number 21JR11RA210, 20JR5RA310 and 20JR5RA298)

语种：英文

外文关键词：antifibrotic therapy; edible plant; hepatic stellate cells; liver disease; liver fibrosis; natural compound

摘要：Liver fibrosis has a high incidence worldwide and is the common pathological basis of many chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular matrix and concomitant collagen accumulation in livers and can lead to the development of liver cirrhosis and even liver cancer. A large number of studies have provided evidence that liver fibrosis can be blocked or even reversed by appropriate medical interventions. However, the antifibrosis drugs with ideal clinical efficacy are still insufficient. The edible plant-derived natural compounds have been reported to exert effective antifibrotic effects with few side-effects, representing a kind of promising source for the treatment of liver fibrosis. In this article, we reviewed the current progress of the natural compounds derived from dietary plants in the treatment of liver fibrosis, including phenolic compounds (capsaicin, chlorogenic acid, curcumin, ellagic acid, epigallocatechin-3-gallate, resveratrol, sinapic acid, syringic acid, vanillic acid and vitamin E), flavonoid compounds (genistein, hesperidin, hesperetin, naringenin, naringin and quercetin), sulfur-containing compounds (S-allylcysteine, ergothioneine, lipoic acid and sulforaphane) and other compounds (betaine, caffeine, cucurbitacin B, lycopene, alpha-mangostin, gamma-mangostin, ursolic acid, vitamin C and yangonin). The pharmacological effects and related mechanisms of these compounds in in-vivo and in-vitro models of liver fibrosis are focused.