文献类型：期刊文献

中文题名：超滤-纳滤集成技术纯化、浓缩当归水提取液的工艺考察

英文题名：Investigation of Purification and Concentration Process for Water Extract of Angelicae Sinensis Radix with Ultrafiltration-nanofiltration Integrated Technology

作者：宋晓春[1];王继龙[1];魏舒畅[1];王志旺[1];金辉[1]

第一作者：宋晓春

机构：[1]甘肃中医药大学药学院

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2016

卷号：22

期号：3

起止页码：13

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：国家自然科学基金项目(81060345)

语种：中文

中文关键词：当归;水提液;超滤工艺;纳滤;阿魏酸

外文关键词：Angelicae Sinensis Radix; water extract; ultrafiltration process; nanofiltration; ferulic acid

摘要：目的:为提高当归水提取物的品质,降低生产成本,研究超滤-纳滤集成技术用于当归水提取液纯化和浓缩的可行性。方法:以阿魏酸保留率为评价指标,以陶瓷膜孔径、工作压强、滤过温度为考察因素,通过正交试验优化当归水提取液的超滤纯化工艺。以阿魏酸泄露率为评价指标,以截留相对分子质量、料液温度为考察因素,通过全面试验确定当归水提取液的纳滤浓缩工艺。结果:当归水提液最佳超滤工艺为膜孔径50 nm,滤过压强0.10 MPa,滤过温度50℃;阿魏酸保留率>90%。当归水提液纳滤浓缩工艺为膜截留相对分子质量200 Da,滤过温度45℃;阿魏酸泄漏率0.1%。结论:超滤-纳滤集成技术纯化、浓缩当归水提取物时,有效成分保留率高、料液受热时间短、能耗低,可提高当归水提物的品质并降低其生产成本。
Objective： To improve quality of water extract of Angelicae Sinensis Radix and reduce production cost by investigating feasibility of purification and concentration process of water extract using ultrafiltration and nanofiltration integrated technology. Method： With retention rate of ferulic acid as index,ceramic membrane pore size,working pressure,filtration temperature as factors,orthogonal test was adopted to optimize ultrafiltration process of water extract of Angelicae Sinensis Radix. With leak rate of ferulic acid as index,interception relative molecular weight and solution temperature as factors,concentration process of ultrafiltrate was optimized by comprehensive test. Result： Optimum ultrafiltration process parameters were as follows： membrane pore size of 50 nm,filtration pressure at 0. 10 MPa,filtration temperature at 50 ℃; retention rate of ferulic acid was more than 90%. Optimum nanofiltration process parameters were as follows： interception relative molecular weight of 200 Da,filtration temperature at 45 ℃; leak rate of ferulic acid was 0. 1%. Conclusion： Ultrafiltration and nanofiltration integrated technology has many advantages,such as retention rate of active ingredients is high and material liquid is heated in a short time,it can improve quality of water extract of Angelicae Sinensis Radix with low production cost.