文献类型：期刊文献

英文题名：Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review

作者：Wang, Chunling[1];Yang, Jiashu[1];Yuan, Jianfang[1];Wang, Xuyong[1];Li, Qianrong[1];Ren, Chunzhen[1];Zhi, Xiaodong[1,2];Lv, Xinfang[2];Liu, Kai[3];Zhao, Xinke[1];Li, Yingdong[1]

第一作者：王臣良;王春蕾

通信作者：Li, YD[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Dept Geriatr, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Med Coll, Pingliang, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：12

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-105002976862);WOS:【SCI-EXPANDED(收录号:WOS:001469174300001)】；

基金：The author(s) declare thatfinancial support was received forthe research and/or publication of this article. This work wassupported by the 2021 Gansu Jiaoyu Jiebang Guashuai Project(No. 2021 JYJBGS-03), 2022 Gansu Province Natural Sciences Fund (22JR11RA128) and National Natural Science Foundation of China (NO. 82260869), National Natural Science Foundation of China (NO. 82360926) and Lanzhou Youth Science and Technology Talents Innovation Project (2023-QN-191).

语种：英文

外文关键词：circadian rhythm; transcription factor; REV-ERB; cardiovascular diseases; biological clock regulation

摘要：Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological processes essential for overall health. REV-ERB, a key circadian clock-regulating gene, plays a crucial role in maintaining the precision of these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health and well-being are increasingly challenged by disruptions to the biological clock, such as night shifts, late-night activities, and jet lag. These disruptions often lead to circadian rhythm disorders, which are now being increasingly linked to heart diseases. This review explored the potential role of REV-ERB in the cardiovascular system. Beyond its role in circadian rhythm regulation, REV-ERB could significantly influence physiological and pathological processes related to cardiovascular health, including atherosclerosis, myocardial ischemia/reperfusion injury, and heart failure. Mechanistically, REV-ERB could regulate glucose and lipid metabolism, inflammation, autophagy, ferroptosis, and mitochondrial function. The review highlighted the protective roles and underlying mechanisms of REV-ERB in cardiovascular diseases, suggesting that multidisciplinary research may provide a basis for breakthroughs in REV-ERB-targeted therapies for cardiovascular disorders.