文献类型：期刊文献

中文题名：基于外泌体抗肿瘤药物递送系统的研究进展

英文题名：Research progress on exosome-based antitumor drug delivery system

作者：孙兴璐[1];刘倩倩[1];刘芳[1];陈彻[1]

第一作者：孙兴璐

机构：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2024

卷号：37

期号：3

起止页码：380

中文期刊名：中国生物制品学杂志

外文期刊名：Chinese Journal of Biologicals

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：甘肃省自然科学基金(20JR10RA311);甘肃省高等学校科研项目(2020JSCX0084);兰州市城关区科技计划项目(2017A-051)。

语种：中文

中文关键词：外泌体;抗肿瘤药物;递送系统

外文关键词：Exosomes;Antitumor drug;Delivery system

摘要：肿瘤是全球相关疾病死亡的主要病因,尽管现有治疗方法已取得重大进展,但缺乏特异性,且生物利用度较低。外泌体是多泡体(multivesicular body,MVB)与质膜融合时释放介于30~150 nm范围内的脂质双层细胞外囊泡,是细胞间通讯的重要介质,可将蛋白质、脂质、核酸等细胞成分输送至邻近或较远的细胞,从而改变受体细胞的作用。外泌体作为天然纳米载体用于药物输送,可将装载的抗肿瘤药物输送至病灶部位,对各类肿瘤进行针对性治疗,且治疗效果较好。本文对基于外泌体抗肿瘤药物递送系统的优势、药物装载方法及不同细胞来源外泌体在肿瘤治疗中的研究进展作一综述,以期为肿瘤的针对性治疗提供依据。
Tumor is the main cause of global related death.Although the existing treatment methods have made significant progress,the lack of specificity and low bioavailability are still the challenge in the treatment.Exosomes are lipid bilayer extracellular vesicles that were released in the range of 30—150 nm when a multi vesicular body(MVB)fuses with plasma membrane,which are important mediators of intercellular communication,and can transport cellular components such as proteins,lipids and nucleic acids to neighboring or distant cells,thus changing the role of recipient cells.Exosomes have been used as natural nano-carriers for drug delivery.After being loaded with antitumor drugs,they can be delivered to the focus for targeted treatment of various tumors,and the therapeutic effect is good.In this paper,the advantages of exosomes-based antitumor drug delivery system,drug loading methods and the research progress of exosomes from different cells in cancer treatment are reviewed so as to provide important basis for the targeted treatment of cancer.