文献类型：期刊文献

英文题名：Rhein and its derivatives: potential anti-tumor drugs and corresponding targeted mechanism

作者：Li, Xiaoli[1,6];Li, Taotao[2];Ma, Yuan[2];Zhang, Zhaocui[3];Hao, Yunfei[7];Zhao, Li[4,5]

第一作者：Li, Xiaoli

通信作者：Zhao, L[1];Zhao, L[2]

机构：[1]Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Hosp, Dept Rheumatol & Immunol, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Hosp 1, Yingfu Med Sci & Technol Translat Ctr, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Clin Med Coll 1, Lab Ctr, Lanzhou 730000, Peoples R China;[6]Gansu Prov Hosp, Dept Nephrol, Lanzhou 730000, Gansu, Peoples R China;[7]Gansu Prov Hosp, Dept Cerebrovascular Dis, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 1, Yingfu Med Sci & Technol Translat Ctr, Lanzhou 730000, Peoples R China;[2]corresponding author), Lanzhou Univ, Clin Med Coll 1, Lab Ctr, Lanzhou 730000, Peoples R China.

年份：2026

卷号：34

期号：4

外文期刊名：SAUDI PHARMACEUTICAL JOURNAL

收录：;Scopus(收录号：2-s2.0-105047781519);WOS:【SCI-EXPANDED(收录号:WOS:001853181800001)】；

基金：This work was supported by Gansu Provincial Joint Research Fund Project (Grant numbers 24JRRA889) and Natural Science Foundation of Gansu Province (Grant numbers 2JRSRA688).

语种：英文

外文关键词：Rhein; Cancer; Structural modification; Drug repurposing; Natural compounds

摘要：Cancer remains a major global health threat with high morbidity and mortality, and clinical treatment is plagued by drug resistance, poor efficacy and severe side effects, driving the search for novel anti-tumor agents from natural products. Rhein, a natural anthraquinone abundant in Rheum palmatum and other medicinal plants, has emerged as a promising anti-tumor phytochemical due to its diverse pharmacological activities and multi-target action characteristics. This review systematically summarizes the natural distribution, chemical structure and structural modification strategies of rhein, and further elaborate the core targeted signaling pathways of rhein in exerting anti-tumor effects. Finally, we propose future research directions for rhein and its derivatives, including accelerating preclinical-to-clinical translation, optimizing structural modification and developing targeted delivery systems to reduce side effects and improve therapeutic efficacy.