文献类型：期刊文献

中文题名：miRNA相关信号通路对糖尿病肾病的作用机制及中医药干预研究进展

英文题名：Mechanism of miRNA-related Signaling Pathway Against Diabetic Nephropathy and Intervention of Traditional Chinese Medicine: A Review

作者：姜晓雪[1];金智生[1];金彩云[1];陈彦旭[1];张博玲[1];伏瑶琴[1]

第一作者：姜晓雪

机构：[1]甘肃中医药大学中医临床学院,兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2023

卷号：29

期号：4

起止页码：228

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82060854)。

语种：中文

中文关键词：糖尿病肾病;微小核糖核酸(miRNA);信号通路;中医药

外文关键词：diabetic nephropathy;microRNAs(miRNAs);signaling pathway;traditional Chinese medicine

摘要：糖尿病肾病(DN)作为常见的糖尿病慢性微血管并发症之一,现已成为我国终末期肾病肾衰竭的主要病因,严重增加糖尿病患者肾透析及肾移植风险,成为糖尿病患者死亡的主要原因。最新研究表明关于对糖尿病肾病的研究早已步入基因层面,微小核糖核酸(miRNA)是一类内源性可获得的非编码短链RNA分子,通过作用于某一靶点,激活或抑制其介导的信号通路及相关分子,在DN发生发展中发挥重要作用,成为防治DN的重要微观因素。传统中医药诊疗DN历史悠久,具有疗效显著、不良反应少等独特优势。大量研究证明,中医药能够靶向干预miRNA影响多条信号通路,参与调控机体炎症反应、细胞焦亡及间充质转分化等病理改变,延缓了DN病程的进一步发展。因此,作者将基于中医药诊疗途径,以miRNA为新关注点,讨论miRNA的生物发生机制及在疾病相关信号通路中的作用机制,归纳总结中医药靶向miRNA调控疾病相关信号通路对DN的影响,以期为从基因角度出发挖掘中医药干预DN进展方面提供一定的理论参考依据。
Diabetic nephropathy(DN), as one of the common chronic microvascular complications of diabetes, has become the main cause of renal failure in end-stage renal disease in China, increasing the risks of renal dialysis and kidney transplantation in diabetes patients. It is the leading cause of death in people with diabetes. The latest research on DN has focused on the gene level. microRNAs(miRNAs) are a family of endogenous accessible short-chain non-coding RNA molecules. By acting on a particular target, they activate or inhibit its mediated signaling pathways and related molecules, playing an important role in the occurrence and development of DN. They have become microeconomic factors for the prevention and treatment of DN.Traditional Chinese medicine(TCM) has a long history in the diagnosis and treatment of DN and has unique advantages such as significant curative effect and few side effects. A large number of studies have proved that TCM can target miRNA to affect multiple signaling pathways, participate in the regulation of inflammatory response, pyroptosis, mesenchymal transdifferentiation, and other pathological changes, and delay the further development of DN. Therefore, this study discusses the biogenesis mechanism of miRNA and its action mechanism in disease-related signaling pathways based on TCM diagnosis and treatment approaches from the perspective of miRNA, and summarizes the effect of TCM targeting miRNA on the disease-related signaling pathways and on DN. Thus, this study is expected to provide a theoretical reference for exploring the progress of TCM intervention in DN from the perspective of genes.