文献类型：期刊文献

中文题名：前列腺素E_1对大鼠胃窦肌电活动的影响

英文题名：EFFECT OF PROSTAGLANDIN E 1 ON RAT'S ANTRAL MYOELECTRIC ACTIVITY

作者：李红芳[1,2];汪龙德[1,2];秦晓民[1,2]

第一作者：李红芳

机构：[1]兰州医学院生理教研室;[2]甘肃中医学院附属医院

第一机构：兰州医学院生理教研室

年份：1998

卷号：19

期号：6

起止页码：434

中文期刊名：动物学研究

外文期刊名：ZOOLOGICAL RESEARCH

收录：CSTPCD;;Scopus;CSCD:【CSCD2011_2012】；PubMed;

语种：中文

中文关键词：前列腺素E_1;胃窦肌电;肾上腺素能受体;胆碱能M受体

外文关键词：Prostaglandin E 1 (PGE 1),Antral myoelectric activity,Adrenergic receptor,Cholinergic M receptor

摘要：用慢性实验方法，在３０只Ｗｉｓｔａｒ大鼠胃窦部浆膜面埋置Ａｇ／ＡｇＣｌ双极电极，观察腹腔注射前列腺素Ｅ１（ｐｒｏｓｔａｇｌａｎｄｉｎＥ１，ＰＧＥ１）对胃窦肌电活动的影响。结果发现ＰＧＥ１：①可降低慢波振幅；②使快波振幅呈现先抑制后增强的双相性变化，其增强时间较短；③导致腹泻。ＰＧＥ１对慢波和快波的抑制作用与肾上腺素能α和β受体无关，对快波的兴奋作用可能经由胆碱能Ｍ受体。
The effect of abdomnoinjection prostaglandin E 1(PGE 1) on antral myoelectric activity was investigated in 30 Wistar rats chronically implanted with Ag/AgCl bipolar electrode on the serosal surface of antrum. It was found that PGE 1 could ① decrease the amplitude of slow wave;② cause biphasic changes of fast wave,usually with enhancement before giving way to inhibition;③ cause diarrhea. The inhibitory action of PGE 1 on slow wave and fast wave might be not mediated via adrenergic α and β receptor,and the excitatory action of PGE 1 on fast wave was probably mediated via cholinergic M receptor.