文献类型：期刊文献

英文题名：Late-onset anti-Yo antibody-positive paraneoplastic cerebellar degeneration: a case report

作者：Zhang, Zhenyu[1,2];Guo, Man[1,2];Zhao, Guohui[1,2];Li, Chenglong[1];Ma, Yong[1];Zhou, Jie[1,2];Cai, Zhibiao[1]

第一作者：Zhang, Zhenyu

通信作者：Zhou, J[1];Cai, ZB[1];Zhou, J[2]

机构：[1]Chinese PLA, Hosp Joint Logist Support Force 940, Dept Neurosurg, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China

第一机构：Chinese PLA, Hosp Joint Logist Support Force 940, Dept Neurosurg, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Chinese PLA, Hosp Joint Logist Support Force 940, Dept Neurosurg, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：12

外文期刊名：FRONTIERS IN SURGERY

收录：;Scopus(收录号：2-s2.0-105028517378);WOS:【SCI-EXPANDED(收录号:WOS:001669545900001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. The 940th Hospital of Joint Logistics Support force of PLA G Program (Project No: 2024-G3-3).

语种：英文

外文关键词：anti-Yo antibody; ataxia; cancer; late-onset; ovarian; paraneoplastic cerebellar degeneration; vertigo

摘要：Anti-Yo antibody-positive paraneoplastic cerebellar degeneration (PCD) is a rare immune-mediated neurological syndrome associated with malignancy, presenting significant diagnostic and therapeutic challenges. This case describes an elderly female patient who developed delayed-onset subacute cerebellar symptoms three years after ovarian cancer resection, ultimately diagnosed with anti-Yo antibody-positive PCD. Although immunotherapy was administered, the patient's ataxia exhibited only limited improvement, suggesting that PCD may progress to an irreversible pathological stage. This case challenges the conventional understanding that PCD typically precedes tumour detection, offering a new perspective on clinical diagnosis and management due to the three-year interval. This case underscores the importance of considering paraneoplastic etiology in patients with unexplained neurological deficits who have a history of tumor surgery. Maintaining awareness for long-term screening for PCD and early management of primary malignancies alongside immunological interventions is crucial for delaying disease progression.