文献类型：期刊文献

中文题名：基于肠?肺轴理论探讨肠道菌群与慢性阻塞性肺疾病关系研究进展

英文题名：Relationship between gut microbiota and COPD based on gut-lung axis theory:advances in research

作者：牛明慧[1];后叶虎[2];杨开燕[1]

第一作者：牛明慧

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000;[2]天水市第二人民医院

第一机构：甘肃中医药大学第二附属医院

年份：2025

卷号：37

期号：1

起止页码：112

中文期刊名：中国微生态学杂志

外文期刊名：Chinese Journal of Microecology

收录：;北大核心:【北大核心2023】；

基金：甘肃省自然科学基金(21JR7RA581)。

语种：中文

中文关键词：肠?肺轴;肠道菌群;慢性阻塞性肺疾病;炎症

外文关键词：Gut–lung axis;Gut microbiota;Chronic obstructive pulmonary disease;Inflammation

摘要：目前,慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)发病机制的研究进展有限,但多项研究表明,肺部炎症仍是诱发COPD的主要因素,炎症反应贯穿COPD的整个过程。慢性炎症与肺部或肠道中菌群的改变有关,这两个器官中的菌群作为联系枢纽,构成了一个连接肺部与肠部的双向轴。其中,高纤维饮食和益生元通过肠道菌群产生短链脂肪酸(short-chain fatty acids,SCFAs)等抗炎分子,这些分子通过血流到达肺部,减缓COPD的发展。然而肠道菌群在调节COPD炎症反应中的作用目前尚无定论。基于此,本研究将对肠道菌群参与COPD炎症反应的相关机制进行总结,以期为防治COPD提供新的思路和策略。
At present,the progress in research on chronic obstructive pulmonary disease(COPD)pathogenesis is limited,but a number of studies have shown that pulmonary inflammation is still the main factor inducing COPD,and the inflammatory response runs through the whole process of COPD.Chronic inflammation is associated with alterations in the microbiota of the lungs or intestines,and the microbiota in these two organs act as a connecting hub and constitute a bidirectional axis connecting the lungs to the intestines.Among them,high-fiber diets and prebiotics produce anti-inflammatory molecules such as short-chain fatty acids(SCFAs)through gut microbiota,which will reach the lungs through the bloodstream to alleviate the development of COPD.However,there is no conclusive evidence on the role of gut microbiota in modulating inflammatory responses in COPD.Based on this,this study will summarize the mechanisms involved in the inflammatory response of COPD by gut microbiota in order to provide new ideas and strategies for the prevention and treatment of COPD.