文献类型：期刊文献

英文题名：The efficacy and safety of glucocorticoid for perioperative patients with hepatectomy: a systematic review and meta-analysis

作者：Liu, Lili[1,2];Zhang, Chengren[2,3];Lu, Tingting[4,5];Li, Xiong[2,3];Jiang, Zhiliang[1,2];Tian, Hongwei[2];Hao, Xiangyong[2];Yang, Kehu[4,6,7];Guo, Tiankang[1,2,8]

第一作者：刘玲玲;Liu, Lili

通信作者：Yang, KH[1];Guo, TK[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Peoples Hosp, Dept Gen Surg, Lanzhou, Gansu, Peoples R China;[3]Ningxia Med Univ, Gen Hosp, Yinchuan, Ningxia, Peoples R China;[4]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China;[5]Gansu Prov Peoples Hosp, Inst Clin Res & Evidence Based Med, Lanzhou, Gansu, Peoples R China;[6]Lanzhou Univ, Key Lab Evidence Based Med & Knowledge Translat Ga, Lanzhou, Gansu, Peoples R China;[7]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China;[8]Gansu Prov Peoples Hosp, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Peoples Hosp, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China.

年份：2023

卷号：17

期号：1

起止页码：59

外文期刊名：EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY

收录：;Scopus(收录号：2-s2.0-85145491179);WOS:【SCI-EXPANDED(收录号:WOS:000905940500001)】；

语种：英文

外文关键词：Glucocorticoids; hepatectomy; perioperative period; meta-analysis

摘要：ObjectiveGlucocorticoids have been used in patients undergoing perioperative hepatectomy, however their safety and efficacy remain controversial. This meta-analysis was conducted to investigate this issue and further provide reference for clinical practice.MethodsPubMed/MEDLINE, Embase, and Cochrane Library were searched for randomized controlled trials (RCTs) from database inception to December 2022. Literature screening and data extraction were performed independently by two reviewers. The methodological quality of the RCTs was assessed using the Jadad scale. RevMan 5.4 was used for the meta-analysis.ResultsA total of 11 RCTs involving 905 patients were included. Compared with the control group, we found perioperative glucocorticoid administration significantly lowered overall complication rate [RR = 0.67; 95% CI (0.55, 0.83); P = 0.0003], infectious complication rate [RR = 0.41; 95% CI (0.21, 0.82); P = 0.01] and postoperative liver failure [RR = 0.63; 95% CI (0.41, 0.97); P = 0.03]. In addition, glucocorticoids appear to improve liver function (TBil) [MD = -0.36, 95% CI (-0.59, -0.14), P = 0.001] and reduce the release of certain inflammatory cytokines (IL-6) [MD = -48.52, 95% CI (-56.88, -40.16), P ConclusionBased on the available evidence, glucocorticoids appear to be safe and effective in patients undergoing hepatectomy, but further research is needed.