文献类型：期刊文献

中文题名：Nrf2/HO-1信号通路在骨质疏松症中的作用及中药干预研究进展

英文题名：Role of Nrf2/HO-1 Signaling Pathway in Osteoporosis and Chinese Medicine Intervention:A Review

作者：赵继荣[1];蒋鹏[1];陈文[2];肖霞萍[1];王兴盛[2];陈倩文[1];马俊飞[1];杨正汉[1]

第一作者：赵继荣

机构：[1]甘肃中医药大学,兰州700030;[2]甘肃省中医院,兰州730050

第一机构：甘肃中医药大学

年份：2022

卷号：28

期号：20

起止页码：241

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(81760877);甘肃省科技重大项目(21ZD4FA009);中医药循证能力建设项目(2019xzzx-GK005)。

语种：中文

中文关键词：核因子E2相关因子2(Nrf2)/血红素氧合酶-1(HO-1)信号通路;骨质疏松症;中药;氧化应激;机制;

外文关键词：nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling pathway;osteoporosis;Chinese medicine;oxidative stress;mechanism;

摘要：骨质疏松症是以骨量低和骨组织微结构破坏、骨稳态失衡为特征的慢性骨骼疾病,导致骨脆性增加和骨折风险增加,产生的过量活性氧(ROS)与抗氧化系统之间的平衡被打破导致的氧化应激是骨质疏松症发生和进展的重要因素。核因子E2相关因子2(Nrf2)/血红素氧合酶-1(HO-1)是重要的抗氧化应激通路,Nrf2是调节细胞氧化应激的主要因素,激活Nrf2可以刺激HO-1的表达,HO-1是一种关键的酶,其代谢产物胆绿素、一氧化碳和游离铁可以清除活性氧,从而在细胞中发挥抗氧化作用。目前,已有国内外学者研究报道,Nrf2/HO-1信号通路与骨质疏松症的发生发展及药物作用机制密切相关。中药具有重要的多靶点、多途径和多层次的优势,可以有效解决西药的不足,中药可以通过调控Nrf2/HO-1信号通路抗氧化应激、抗炎症反应、抗细胞凋亡等,从而治疗骨质疏松症。本文综述了Nrf2/HO-1信号通路及其中关键靶点蛋白因子与骨质疏松症的关系,以明确Nrf2/HO-1信号通路对骨质疏松症的重要作用。同时,对靶向调控Nrf2/HO-1信号通路来治疗骨质疏松症的中药进行系统性总结,以期为骨质疏松症的进一步精准治疗提供理论依据。
Osteoporosis is a chronic skeletal disease characterized by low bone mass,destruction of bone tissue microarchitecture,and imbalance of bone homeostasis,leading to increased bone fragility and increased risk of fractures.Oxidative stress caused by the disruption of the balance between excess reactive oxygen species(ROS)and the anti-oxidative system is an important factor in the occurrence and progression of osteoporosis.Nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)is an important anti-oxidative stress pathway.Nrf2 is a primary factor in regulating cellular oxidative stress.Activating Nrf2 can stimulate the expression of HO-1.HO-1 is a key enzyme whose metabolites are bile green Oxygen,carbon monoxide,and free iron.The metabolites can scavenge ROS,thereby exerting an antioxidant effect in cells.At present,domestic and foreign scholars have reported that the Nrf2/HO-1 signaling pathway is closely related to the occurrence and development of osteoporosis and the mechanism of drugs.Chinese medicine can effectively solve the insufficiency of western medicine with multi-target,multi-channel,and multi-level advantages.Chinese medicine can resist oxidative stress,inflammatory response,and apoptosis by regulating the Nrf2/HO-1signaling pathway,thus treating osteoporosis.This article reviewed the relationship between Nrf2/HO-1signaling pathway and its key target protein factors and osteoporosis,to clarify the important role of the Nrf2/HO-1 signaling pathway in osteoporosis.At the same time,a systematic summary of Chinese medicines targeting and regulating the Nrf2/HO-1 signaling pathway for the treatment of osteoporosis was conducted,to provide a theoretical basis for further precise treatment of osteoporosis.