文献类型：期刊文献

英文题名：Linking Triglyceride-Glucose Index to Spontaneous Intracerebral Hemorrhage: Mechanisms and Predictive Insights

作者：Wang, Jiahao[1,2];Zhou, Yanling[1,2];Song, Yuruo[1,2];Fang, Qi[1,2];Xia, Juan[1,2];Tao, Pengxian[3,4,5];Ma, Haizhong[2,3,4];Zhang, Dongzhi[1,2,3,4,6]

第一作者：王谨慧;Wang, Jiahao

通信作者：Zhang, DZ[1];Zhang, DZ[2];Zhang, DZ[3];Zhang, DZ[4];Zhang, DZ[5]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Emergency Dept, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Gansu, Peoples R China;[4]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Gansu, Peoples R China;[5]Gansu Prov Hosp, Cadre Ward Gen Surg Dept, Lanzhou, Gansu, Peoples R China;[6]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Emergency Dept, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Gansu, Peoples R China;[4]corresponding author), Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Gansu, Peoples R China;[5]corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：31

外文期刊名：MEDICAL SCIENCE MONITOR

收录：;Scopus(收录号：2-s2.0-105009255716);WOS:【SCI-EXPANDED(收录号:WOS:001515379800001)】；

基金：This work was supported by the 2024 Lanzhou Science and Technology Planning Project (2024-9-19) and the Clinical Research Project (23GSSYD-22)

语种：英文

外文关键词：Cerebral Hemorrhage; Glucose; Glucose Intolerance

摘要：Spontaneous intracerebral hemorrhage (SICH) is a fatal subtype of stroke, closely associated with multiple risk factors, particularly metabolic abnormalities. In recent years, the triglyceride-glucose (TyG) index has emerged as a novel biomarker for metabolic syndrome, attracting growing attention from both the clinical and research communities. The TyG index is calculated based on triglyceride and fasting glucose levels and has been demonstrated to be closely related to insulin resistance, inflammatory responses, and cardiovascular diseases. This review aims to explore the potential association between the TyG index and SICH and to analyze its value in the early prediction of intracerebral hemorrhage. First, we provide an overview of the pathological mechanisms underlying SICH, with a focus on the roles of hypertension, vascular pathological changes, and metabolic dysregulation in its occurrence. Second, we examine the biological significance of the TyG index in metabolic abnormalities, insulin resistance, and lipid metabolism disorders, particularly its predictive role in cardiovascular and cerebrovascular diseases. Lastly, we discuss the clinical application of the TyG index in the early prediction of SICH, emphasizing its advantages as a simple, cost-effective, and easily implementable screening tool that can aid clinicians in identifying and intervening in high-risk populations. This article aims to review the association between the TyG index and intracerebral hemorrhage.