文献类型：期刊文献

中文题名：经典名方防治失眠的研究进展

英文题名：Research progress in the prevention and treatment of insomnia with classical prescriptions

作者：石晓雨[1,2];陈丽萍[1,2];李文斌[1];王荣[1]

第一作者：石晓雨

机构：[1]中国人民解放军联勤保障部队第九四〇医院药剂科,兰州730050;[2]甘肃中医药大学药学院,兰州730050

第一机构：中国人民解放军联勤保障部队第九四〇医院药剂科,兰州730050

年份：2023

卷号：48

期号：10

起止页码：1494

中文期刊名：中南大学学报（医学版）

外文期刊名：Journal of Central South University ：Medical Science

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；PubMed;

基金：甘肃省科技计划重大专项(23ZDFA013-5);第九四〇医院部队面上项目(2021yxky082);第九四〇医院院内项目(2023YXKY016)。

语种：中文

中文关键词：经典名方;失眠;机制

外文关键词：classical prescriptions;insomnia;mechanism

摘要：失眠是一种常见疾病,对人体健康的影响不容忽视。目前,失眠的临床治疗主要有中医药治疗、镇静催眠类药物治疗与认知行为疗法3种方法,中医药治疗失眠以其不良反应低、疗效好、无药物依赖性等优点而被广泛应用。对中西医理论中失眠病机进行概括,现代医学研究普遍认为失眠以睡眠-觉醒障碍为主要病理机制,涉及单胺类神经递质紊乱、细胞因子失衡、肠道菌群失衡等多个因素;中医将失眠病机主要划分为肝郁化火、阴虚火旺、痰热内扰、心肾不交、心脾两虚、心胆气虚、胃气不和、心火炽盛、瘀血内阻9类证型。根据上述9种失眠病机,对应的经典名方如龙胆泻肝汤、酸枣仁汤、黄连温胆汤、交泰丸、归脾汤等进行分析与总结,发现中药主要通过升高5-羟色胺水平,降低多巴胺、去甲肾上腺素、肿瘤坏死因子α及白细胞介素-6水平和谷氨酸与γ-氨基丁酸的比值,抑制下丘脑-垂体-肾上腺轴等起到治疗失眠的效果。
Insomnia is a common disease and its impact on human health cannot be ignored.At present,there are 3 main clinical treatments for insomnia,including traditional Chinese medicine treatment,sedative hypnotic drug therapy,and cognitive behavioral therapy.Traditional Chinese medicine(TCM)treatment for insomnia is widely used due to its advantages of low side effects,good efficacy,and no drug dependence.This paper summarizes the pathogenesis of insomnia in the theories of traditional Chinese and Western medicine.Modern medical research generally believes that sleep-wake disorder is the main pathological mechanism of insomnia,involving many factors such as monoamine neurotransmitter disorder,cytokine imbalance and intestinal flora imbalance.TCM mainly divides the pathogenesis of insomnia into 9 kinds of syndrome types:Liver depression transforming into fire,hyperactivity of fire due to yin deficiency,phlegm-heat attacking internally,disharmony between heart and kidney,deficiency of both heart and spleen,qi deficiency of both heart and gallbaldder,stomach qi disharmony,exuberance of heart fire,and internal blockade of static blood.According to these 9 kinds of pathogenesis of insomnia,the corresponding classical prescriptions such as Longdanxiegan decoction,Suanzaoren decoction,Huanglian-Wendan decoction,Jiaotai pill and Guipi decoction were analyzed and summarized.There is evidence that traditional Chinese medicine could treat insomnia mainly by increasing the level of 5-hydroxytryptamine,reducing the levels of dopamine,noradrenaline,tumor necrosis factorα,and interlukin-6,decreasing the ratio of glutamic acid toγ-aminobutyric acid,and inhibiting the hypothalamic-pituitary-adrenal axis.