文献类型：期刊文献

中文题名：中医药调控Wnt/β-catenin信号通路治疗激素性股骨头坏死的研究进展

英文题名：Traditional Chinese Medicine Regulates Wnt/β-catenin Signaling Pathway to Treat Steroid-induced Femoral Head Necrosis: A Review

作者：尚征亚[1];曹林忠[1,2];杨浩东[1];胡康一[1]

第一作者：尚征亚

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：29

期号：20

起止页码：205

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(81860859,82160915)。

语种：中文

中文关键词：激素性股骨头坏死;分泌型糖蛋白/β-连环蛋白(Wnt/β-catenin)信号通路;中医药;研究进展

外文关键词：steroid-induced femur head necrosis;Wnt/β-catenin signaling pathway;traditional Chinese medicine;research progress

摘要：激素性股骨头坏死(SNOFH)是临床上常见的一种骨科疾病,具有治愈难度大、临床预后差等特点。中国每年的SNOFH患者人数还在呈逐年上升的趋势,严重威胁人类的健康。长期不规范或短期大量使用激素(GC)是造成该病发生的重要原因,目前临床上对SNOFH多采取髋关节置换等手术治疗手段,其存在对患者伤害大、花费较高等局限性。近年来,随着对中医药研究的不断深入与创新,运用中医药方法治疗SNOFH在临床上被广泛应用。SNOFH发生的中医病机主要是肾虚血瘀,故临床多采取补肾活血类中药单体及复方对SNOFH进行治疗。且中医药具有治疗效果明显,不良反应小,花费少等优点。在此之前的研究大都从中医辨证的方向阐述中医药对SNOFH的影响,该文从分子生物及细胞生物学角度来阐述中医药对SNOFH的影响机制。分泌型糖蛋白/β-连环蛋白(Wnt/β-catenin)信号通路作为与骨骼密切相关的经典信号通路,其通过促进骨髓间充质干细胞更新、增强成骨细胞的活性并抑制其发生凋亡,从而调节骨组织的代谢平衡,增加骨密度,在骨形成的过程中发挥重要作用。近年来运用中药单体及复方调控Wnt/β-catenin信号通路治疗SNOFH已成为当今研究的新热点。现就中医药通过调控Wnt/β-catenin信号通路防治SNOFH的研究进展做一综述,以期为中医药治疗SNOFH的应用提供参考。
Steroid-induced necrosis of the femoral head(SNOFH)is a common orthopedic disease,which is difficult to cure and has poor clinical prognosis.The number of SNOFH patients in China is still increasing year by year,which seriously threatens human health.Long-term non-standard or short-term extensive use of hormone(GC)is an important reason for the occurrence of this disease.At present,SNOFH is mostly treated by surgical methods such as hip replacement,which has limitations of great harm to patients and high cost.In recent years,with the continuous deepening and innovation of traditional Chinese medicine(TCM)research,the use of TCM to treat SNOFH has been widely used in clinical practice.The main TCM pathogenesis of SNOFH is kidney deficiency and blood stasis.Therefore,TCM monomer and compound compound of tonifying kidney and promoting blood circulation are used to treat SNOFH.And TCM has obvious therapeutic effect,small side effects,less cost and other advantages.Glycoprotein/beta chain protein secretion(Wnt/betacatenin)signaling pathway as a classic signaling pathway is closely related to the bone,between its by promoting bone marrow mesenchymal stem cell update,enhance the activity of osteoblast and suppress the apoptosis,which adjust the metabolic balance of bone tissue,increase bone density,will play an important role in the process of bone formation.In recent years,the use of TCM monomers and compounds to regulate Wnt/β-catenin signaling pathway to accelerate bone marrow mesenchymal stem cells,promote their transformation into osteoblasts,and maintain bone metabolic balance mechanism to treat SNOFH has become a new research hotspot.This article reviews the research progress of TCM in the prevention and treatment of SNOFH by regulating Wnt/β-catenin signaling pathway,in order to provide reference for the application of TCM in the treatment of SNOFH.