文献类型：期刊文献

中文题名：推拿手法对实验性类风湿性关节炎家兔疼痛的影响

英文题名：Analgesia Effect of Tuina on Pain of Experimental Rheumatoid Arthritis Rabbits

作者：王念宏[1];李军[2];裴明[3]

第一作者：王念宏

机构：[1]上海中医药大学附属岳阳中西医结合医院;[2]甘肃中医学院;[3]上海中医药大学针推学院

第一机构：上海中医药大学附属岳阳中西医结合医院

年份：2007

卷号：9

期号：6

起止页码：180

中文期刊名：辽宁中医药大学学报

外文期刊名：Journal of Liaoning University of Traditional Chinese Medicine

收录：CSTPCD

语种：中文

中文关键词：推拿;类风湿性关节炎;β-EP;CCK-8;镇痛

外文关键词：Tuina; rheumatoid arthritis ; β -EP; CCK-8; ease pain

摘要：目的:观察推拿手法对实验性类风湿性关节炎(RA)家兔疼痛的影响并探讨其镇痛作用的机理。方法:将32只家兔随机分为4组,正常组、模型组、药物组、推拿组。除正常组外,其他3组用卵蛋白诱导法复制RA家兔疼痛模型,药物组给予3次/天,连续10天的药物(痹颗粒)治疗、推拿组给予1次/天,连续10天的推拿治疗,治疗结束后用钾离子透入法测定各组家兔膝关节局部痛阈,然后抽取脑脊液(CSF),用放免法检测CSF中β-内啡肽(β-EP)和八肽胆囊收缩索(CCK-8)的含量,比较药物组、推拿组关节炎家兔关节局部痛阈和脑脊液中β-EP和CCK-8的含量。结果:推拿组、药物组痛阈和β-EP含量均升高(P<0.05),推拿组β-EP的含量高于药物组(P<0.05),推拿组、药物组CCK-8的含量均向正常水平恢复,但低于正常组(P<0.05)。结论:推拿和中药对RA家兔都有镇痛作用,其作用的中枢机理之一可能与内源性阿片肽β-EP的大量释放和促使CCK-8含量向正常水平的恢复有关。
Objective：To observe the Analgesia effect of Tuina therapy on pain of the experimental rheumatoid arthritis （ RA ） rabbits and explore its central analgesic mechanism. Methods ： thirty-two rabbits were randomized into control （ n=8 ）, model （ n=8 ）, medication （ n=8 ）, Tuina （ n=8 ） groups.RA model was established. Medication group was administered with ＂Wangbi Granule＂ through gastric tube,0.56g/ time, three times a day, continuously for 10 days.Tuina group was treated with Tuina manipulations once a day also 10 days. The pain threshold was detected in the surface of the knee with K＋ penetration dolorimeter,β -EP and CCK-8 contents in ccrebrospinal fluid were assayed with radioimmunoassay. Results ： compared with control group, the pain threshold and CCK-8 contents of model group lowered significantly （ P〈0.05 ）, β -EP of model group increased significantly （ P〈0.05 ）; while in comparison with model group, the pain threshold and CCK-8 contents of medication and Tuina groups both increased significantly （ P〈0.05 ）, but CCK-8 contents of two treat groups significantly lower than control group. The effects of Tuina group were significantly superior to medication group in raising β -EP and CCK-8 levels （ P〈0.05 ） .Conclusion ： Tuina manipulation and Chinese herbal medicine method both have analgesic effect in rheumatoid arthritis rats, which is probably related to their effects in raising cerebral β -EP and CCK-8.