文献类型：期刊文献

英文题名：High performance non-enzymatic glucose biosensor based on copper nanowires-carbon nanotubes hybrid for intracellular glucose study

作者：Huang, Jingwei[1];Dong, Zhengping[1];Li, Yingdong[2];Li, Jing[1];Wang, Jia[1];Yang, Haidong[1];Li, Shuwen[1];Guo, Shujing[1];Jin, Jun[1];Li, Rong[1]

第一作者：Huang, Jingwei

通信作者：Jin, J[1]

机构：[1]Lanzhou Univ, Gansu Prov Engn Lab Chem Catalysis, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Inst Integrated Tradit & Western Med, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Gansu Prov Engn Lab Chem Catalysis, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Gansu Prov Engn Lab Chem Catalysis, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.

年份：2013

卷号：182

起止页码：618

外文期刊名：SENSORS AND ACTUATORS B-CHEMICAL

收录：;EI(收录号：20131716224928);Scopus(收录号：2-s2.0-84876271118);WOS:【SCI-EXPANDED(收录号:WOS:000319488800084)】；

基金：This research is supported by the Fundamental Research Funds for the Central Universities (lzujbky-2013-67, lzujbky-2012-68).

语种：英文

外文关键词：Copper nanowire; Multi-walled carbon nanotube; Intracellular; Glucose; Non-enzymatic; Electrochemical biosensor

摘要：In order to detect low concentration of glucose in cell sample conveniently, a glucose biosensor with high sensitivity and low detection limit was fabricated by modifying one-dimensional ultra-long Cu nanowires (Cu NWs) and multi-walled carbon nanotubes (MWCNTs) hybrid on the surface of glassy carbon electrode (GCE). Cu NWs with uniform diameter were synthesized by a facile approach in large scale and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD). The electrocatalytic activity of the as-prepared biosensor towards glucose oxidation was investigated by cyclic voltammetry and amperometric measurement in alkaline media. The results showed that the biosensor exhibited a rapid response time of less than 1 s and high sensitivity of 1995 mu Am M-1 cm(-2) with a wide linear range (up to 3 mM) and low detection limit (0.26 mu M at signal/noise ratio (S/N)= 3). For practical application, the biosensor was successfully applied to detect glucose in serum and study the relationship between the glucose concentrations in cultivated cells and the glucose concentrations in culture mediums, in which the cells were cultivated. All the experiment results showed that the Cu NWs-MWCNTs hybrid had great potential applications in the development of biosensors for enzyme-free detection of low concentration glucose. (C) 2013 Elsevier B.V. All rights reserved.