文献类型：期刊文献

英文题名：Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome

作者：Li, Yue[1];Liu, Qingju[1,2];Kang, Chengdong[3];Cui, Weijing[4];Xu, Zichuan[3];Zhong, Fu[3];Gao, Xia[3]

第一作者：李洋;李勇;李燕;李芸;李杨;李瑶;李晔;李阳;李颖

通信作者：Gao, X[1]

机构：[1]Gansu Univ Chinese Med, Grad Sch, Lanzhou 730000, Peoples R China;[2]Fifth Peoples Hosp Chengdu, Dept Pediat, Chengdu 611130, Peoples R China;[3]Guangzhou Women & Childrens Med Ctr, Dept Nephrol, Guangzhou 510623, Peoples R China;[4]Gansu Prov Hosp, Pediat Dept, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Guangzhou Women & Childrens Med Ctr, Dept Nephrol, Guangzhou 510623, Peoples R China.

年份：2021

卷号：22

期号：1

外文期刊名：BMC NEPHROLOGY

收录：;Scopus(收录号：2-s2.0-85104274361);WOS:【SCI-EXPANDED(收录号:WOS:000640191700001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (Grant No. 81660130) and the Natural Science Foundation of Gansu Province, China (Grant No. 18JR3RA045).

语种：英文

摘要：Background This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria. Methods ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls. Results Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 (P < 0.001). In primary nephrotic syndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r = 0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while there was no correlation with 24 hUTP. Urine ANGPTL8 was positively correlated with high-density lipoprotein cholesterol (r = 0.181, P < 0.05) and was significantly negatively correlated with creatinine (r = - 0.323, P < 0.001), eGFR (r = - 0, P < 0.001) and 24 hUTP (r = - 0.268, P = 0.002). Interestingly, the urine ANGPTL8 concentrations in membranous nephropathy and mesangial proliferative glomerulonephritis pathological types were different. Conclusions Serum and urine ANGPTL8 levels in primary nephrotic syndrome patients were correlated with blood lipid levels and proteinuria, respectively, suggesting that ANGPTL8 may play a role in the development of primary nephrotic syndrome hyperlipidemia and proteinuria.