文献类型：期刊文献

中文题名：半夏泻心汤防治GC作用机制研究进展

英文题名：Mechanism of Banxia Xiexintang in Prevention and Treatment of Gastric Cancer:A Review

作者：张艳美[1];魏晶晶[1];朱中博[1];刘森雨[2];杨帆[1,3];刘喜平[1];李沛清[1]

第一作者：张艳美

机构：[1]甘肃中医药大学甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州730000;[2]海南医学院第一临床学院,海口571199;[3]海南医学院中医学院,海口571199

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2023

卷号：29

期号：10

起止页码：65

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(81260525,81860813,81860782,82260895)。

语种：中文

中文关键词：半夏泻心汤;胃癌;物质基础;作用机制;研究进展

外文关键词：Banxia Xiexintang;gastric cancer;material basis;mechanism;research progress

摘要：胃癌(GC)是常见的恶性肿瘤之一,我国GC的发病率和死亡率居世界首位。目前,GC的发病机制尚未完全阐明。虽然手术、放化疗、靶向治疗及免疫治疗等在GC的治疗中获得较好的疗效,但仍会出现并发症多、敏感性降低、不良反应大等问题。半夏泻心汤源自《伤寒杂病论》,临床应用2 000余年,具有寒热平调、散结除痞之效,为后世治疗消化道疾病的经典名方。经临床观察和实验研究,发现半夏泻心汤及其中单味药在防治GC方面具有较好的效果。中药因具有多成分、多靶点的特点,可以通过多种作用机制治疗GC。因此,需要从分子生物学、网络药理学等层面进行系统深入的研究,全面揭示半夏泻心汤防治GC的作用机制。目前半夏泻心汤治疗GC的作用机制主要集中于诱导GC细胞凋亡,抑制GC细胞的增殖、迁移、侵袭,保护腹膜间皮细胞,阻抑GC细胞腹膜转移,调节GC微环境,抑制骨髓间充质干细胞(BMSCs)的恶性转化等。本课题组致力于半夏泻心汤防治GC的研究,旨在全面地揭示半夏泻心汤防治GC的作用机制及其药效物质基础,为半夏泻心汤的进一步临床应用提供重要科学依据。该文通过检索中国知网(CNKI)、PubMed、万方(Wanfang Data)、维普(VIP)等数据库,从方证基础、物质基础、网络药理学、临床与实验研究等方面对半夏泻心汤治疗GC进行归纳与梳理,为进一步研究半夏泻心汤的药理作用并将其应用于临床GC的治疗提供参考依据。
Gastric cancer(GC)is one of the common malignant tumors,and the incidence and mortality of GC in China rank first in the world.At present,the pathogenesis of GC has not been fully clarified.Although surgery,radiotherapy,chemotherapy,targeted therapy,and immunotherapy have achieved good results in the treatment of GC,there are still many complications,decreased sensitivity,and severe side effects.Banxia Xiexintang,derived from Treatise on Cold Damage and Miscellaneous Diseases(《伤寒杂病论》),has been clinically used for more than 2000 years with the effects of combining cold and warm drugs,dissipating mass,and relieving stuffiness,and is a classic prescription for treating digestive tract diseases in later generations.Through clinical observation and experimental research,it is found that Banxia Xiexintang and its single drugs have good effect in preventing and treating GC.Chinese medicine has multi-component and multi-target characteristics and can treat GC through various mechanisms.Therefore,it is necessary to carry out systematic and in-depth research from the aspects of molecular biology and network pharmacology,and comprehensively reveal the mechanism of Banxia Xiexintang in preventing and treating GC.At present,the mechanism of Banxia Xiexintang in treating GC mainly focuses on inducing apoptosis of GC cells,inhibiting proliferation,migration,and invasion of GC cells,protecting peritoneal mesothelial cells,inhibiting peritoneal metastasis of GC cells,regulating GC microenvironment,and inhibiting the malignant transformation of bone marrow mesenchymal stem cells(BMSCs).This research group is committed to the prevention and treatment of GC with Banxia Xiexintang,aiming to comprehensively reveal the mechanism of action and the pharmacodynamic material basis of Banxia Xiexintang in the prevention and treatment of GC,and provide an important scientific basis for further clinical application of Banxia Xiexintang.After searching CNKI,PubMed,Wanfang Data,VIP,and other databases,this paper summarized Banxia Xiexintang in the treatment of GC from the aspects of prescription basis,material basis,network pharmacology,clinical and experimental studies,etc.,so as to provide references for further research on pharmacological effect of Banxia Xiexintang and its application in the clinical treatment of GC.