文献类型：期刊文献

英文题名：Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors

作者：Huang, Bingqian[1];Yang, Yulin[2];Liu, Jinming[3];Zhang, Biao[3];Lin, Nengming[1]

第一作者：Huang, Bingqian

通信作者：Lin, NM[1];Zhang, B[2]

机构：[1]Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Key Lab Clin Canc Pharmacol & Toxicol Res Zhejiang, Hangzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Chinese Med, Lanzhou, Gansu, Peoples R China;[3]Dalian Med Univ, Dept Gen Surg, Affiliated Hosp 1, Dalian, Peoples R China

第一机构：Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Key Lab Clin Canc Pharmacol & Toxicol Res Zhejiang, Hangzhou, Peoples R China

通信机构：[1]corresponding author), Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Key Lab Clin Canc Pharmacol & Toxicol Res Zhejiang, Hangzhou, Peoples R China;[2]corresponding author), Dalian Med Univ, Dept Gen Surg, Affiliated Hosp 1, Dalian, Peoples R China.

年份：2025

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105001021935);WOS:【SCI-EXPANDED(收录号:WOS:001450834000001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. We acknowledge financial support from the Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province (2020E10021), Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents (ZWB-2020-18), Zhejiang Medical Key Discipline Foundation (ZWB-2018-02-03), Hangzhou Medical Key Discipline Foundation (HWF-2021-21-16).

语种：英文

外文关键词：mitochondrial homeostasis; ubiquitination; gastrointestinal tumors; mitochondrial biogenesis; mitochondrial dynamics; mitophagy; mitochondrial metabolism

摘要：Mitochondrial homeostasis (MH) refers to the dynamic balance of mitochondrial number, function, and quality within cells. Maintaining MH is significant in the occurrence, development, and clinical treatment of Gastrointestinal (GI) tumors. Ubiquitination, as an important post-translational modification mechanism of proteins, plays a central role in the regulation of MH. Over the past decade, research on the regulation of MH by ubiquitination has focused on mitochondrial biogenesis, mitochondrial dynamics, Mitophagy, and mitochondrial metabolism during these processes. This review summarizes the mechanism and potential therapeutic targets of ubiquitin (Ub)-regulated MH intervention in GI tumors.