文献类型：期刊文献

中文题名：甲状腺疾病与子痫前期风险的因果关联:一项两样本双向孟德尔随机化研究

英文题名：Causal association of thyroid disease with risk of preeclampsia:a two-sample bidirectional Mendelian randomization study

作者：张展[1,2];李建锋[1,2];昂文成林龙珠[3];李燕玲[1,2];王博雯[1,2];李重伟[1,2];梁宇博[1,2];王鑫[4];谢萍[1,2]

第一作者：张展

机构：[1]甘肃省人民医院心血管内科,甘肃兰州730000;[2]甘肃省人民医院心血管病研究中心;[3]兰州大学第一临床医学院;[4]甘肃中医药大学第一临床医学院

第一机构：甘肃省人民医院心血管内科,甘肃兰州730000

年份：2025

卷号：33

期号：4

起止页码：335

中文期刊名：中华高血压杂志(中英文)

外文期刊名：Chinese Journal of Hypertension

收录：;北大核心:【北大核心2023】；

基金：甘肃省国际科技合作项目(20YF3WA011);兰州市人才创新创业项目(2018-RC-72);甘肃省中医药科研课题(GZKZ-2021-7)。

语种：中文

中文关键词：甲状腺功能亢进;甲状腺功能减退;子痫前期;孟德尔随机化

外文关键词：hyperthyroidism;hypothyroidism;preeclampsia;Mendelian randomization

摘要：目的采用双向两样本孟德尔随机化(MR)分析探讨甲状腺疾病(甲状腺功能减退、甲状腺功能亢进)与子痫前期的因果关联。方法基于全基因组关联研究汇总数据集,采用逆方差加权分析(IVW)法、加权中位数(WM)、MR-Egger法、最大似然(ML)法进行MR分析,评估甲状腺疾病与子痫前期的因果关系。同时,进行异质性检验、敏感性分析、多效性分析以确保结果的稳定性。结果MR分析结果表明,甲状腺功能减退(IVW:OR=3.804,95%CI 1.121~12.911;P=0.032)、甲状腺功能亢进(IVW:OR=1.163,95%CI 1.071~1.263;P<0.001)与子痫前期风险增加存在因果关系。然而,在反向MR分析中,未发现子痫前期增加甲状腺疾病异常风险的因果证据。此外,工具变量均不存在多效性,并且留一法也提示所得结果稳健。结论研究通过MR分析揭示了甲状腺功能减退和甲状腺功能亢进与子痫前期风险增加之间的因果关联。然而,子痫前期与甲状腺功能减退和甲状腺功能亢进风险增加不存在因果关系。
Objective To explore the causal relationship between thyroid diseases(hypothyroidism,hyperthyroidism)and preeclampsia using bidirectional two sample Mendelian randomization(MR)analysis.Methods Using summary data from genome-wide association studies(GWAS),MR analyses were conducted by the inverse-variance weighted(IVW)method,weighted median(WM),MR-Egger method,and maximum likelihood(ML)estimation to assess the causality between thyroid diseases and the risk of preeclampsia.Heterogeneity tests,sensitivity analyses,and pleiotropy assessments were also performed to ensure the robustness of the results.Results The MR analysis results showed that hypothyroidism(IVW:OR=3.804,95%CI 1.121-12.911;P=0.032)and hyperthyroidism(IVW:OR=1.163,95%CI 1.071-1.263;P<0.001)were causally associated with an increased risk of preeclampsia.However,in reverse MR analysis,no causal evidence was found between preeclampsia and increased risk of thyroid disease abnormalities.Additionally,no pleiotropy was detected in the instrumental variables,and leave-one-out analysis indicated the results were robust.Conclusions MR analysis revealed a causal relationship between hypothyroidism,hyperthyroidism and the increased risk of preeclampsia.Nevertheless,there is no causal relationship between preeclampsia and an increased risk of either thyroid disorder.