文献类型：期刊文献

中文题名：高血压患者血清MMP-2、TIMP-2、Hcy、UA水平与颈动脉硬化的相关性

英文题名：Correlation analysis of serum levels of MMP-2,TIMP-2,Hcy,UA and carotid atherosclerosis in patients with hypertension

作者：陆玉琴[1];赵信科[1];冯明霞[1];纪召娟[1]

第一作者：陆玉琴

机构：[1]甘肃中医药大学附属医院心血管中心,甘肃兰州730020

第一机构：甘肃中医药大学第二附属医院

年份：2020

卷号：35

期号：7

起止页码：595

中文期刊名：临床荟萃

外文期刊名：Clinical Focus

基金：甘肃省自然科学基金资助项目高血压病合并房颤患者MMPs、TIMP、hs-CRP、Hcy水平的研究(1508RJZA044)。

语种：中文

中文关键词：高血压;颈动脉内中膜厚度;基质金属蛋白酶

外文关键词：hypertension;carotid intima thickness;matrix metalloproteinase

摘要：目的探讨高血压患者血清基质金属蛋白酶2(MMP-2)、基质金属蛋白酶抑制剂2(TIMP-2)、同型半胱氨酸(Hcy)、尿酸(UA)水平与颈动脉内中膜厚度(cIMT)的相关性。方法应用多普勒超声检测364例高血压病患者的cIMT,根据cIMT是否≥1 mm分为cIMT增厚组和cIMT无增厚组;酶联免疫法测定患者血清MMP-2、TIMP-2,同时送检验科测定血清Hcy、UA及血脂水平。分析颈动脉内中膜增厚的独立危险因素。结果与cIMT无增厚组比较,cIMT增厚组年龄、Hcy、UA、MMP-2增加(P<0.05)。cIMT与UA、MMP-2、年龄呈正相关。年龄是颈动脉内中膜增厚的独立危险因素。结论年龄是动脉硬化的独立危险因素,MMP-2、Hcy、TC、LDL-c、UA与动脉硬化有关,但目前尚不能确定为动脉硬化的独立损害因子。
Objective To investigate the correlation between serum levels of matrix metalloproteinase 2(MMP-2),matrix metalloproteinase inhibitor 2(TIMP-2),homocysteine(Hcy),uric acid(UA)and carotid intima-media thickness(cIMT)in patients with hypertension.Methods Doppler ultrasound was used to detect cIMT in 364 patients with hypertension.According to whether cIMT≥1 mm,the patients were divided into cIMT thickening group and cIMT non-thickening group.The serum MMP-2 and TIMP-2 were measured by enzyme-linked immunoassay,and the serum Hcy,UA and lipid levels were determined by laboratory at the same time.The independent risk factors for carotid intima thickening were analyzed.Results Compared with cIMT non-thickening group,the age,Hcy,UA and MMP-2 increased in cIMT thickening group(P<0.05).Age was an independent risk factor for carotid intima thickening.Conclusion Age is an independent risk factor for atherosclerosis.MMP-2,Hcy,TC,LDL-C and UA are associated with atherosclerosis,but they can not be identified as independent damage factors for atherosclerosis at present.