文献类型：期刊文献

中文题名：肠道菌群与肝癌的研究进展

英文题名：Advances in research on intestinal microflora and liver cancer

作者：周熙祥[1];伍志伟[1,2];张录梅[1];薛娜[1];颜春鲁[1]

第一作者：周熙祥

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室

第一机构：甘肃中医药大学

年份：2021

卷号：33

期号：8

起止页码：971

中文期刊名：中国微生态学杂志

外文期刊名：Chinese Journal of Microecology

收录：CSTPCD;;CSCD:【CSCD_E2021_2022】；

基金：甘肃省科技创新基地与人才计划项目(18JR3RA200)。

语种：中文

中文关键词：肠道菌群;肝癌;发病机制

外文关键词：Intestinal microflora;Liver cancer;Pathogenesis

摘要：微生态是微生物与机体在长期进化和相互作用过程中形成的特殊生态系统,对机体健康与疾病起着重要作用。肠道菌群作为人体微生态的重要组成部分,通过营养代谢、免疫调节和基因调控参与人体内一系列重要的生理和病理过程。肠道菌群失调可导致胆汁酸代谢异常、内毒素释放、肠道稳态破坏、模式识别受体激活等,这些都可直接或间接促进肝癌的发展。本文从以上因素着手,通过文献检索对肠道菌群与肝癌发生发展关系的研究作一简要综述。
Microecology is a special ecosystem formed by microorganisms and organisms in the process of long-term evolution and interaction, which plays an important role in the process of organism health and diseases. As an important part of human microecology, intestinal microflora participates in a series of important physiological and pathological processes through nutrition metabolism, immune regulation and gene regulation. The imbalance of intestinal flora can lead to abnormal metabolism of bile acid, release of endotoxin, destruction of intestinal homeostasis, and activation of pattern recognition receptors, etc., all of which can directly or indirectly promote the development of liver cancer.Based on the factors above, this paper makes a brief review of the researches on the relationship between intestinal flora and the development of liver cancer.