文献类型：期刊文献

中文题名：辛扶洗剂联合达泊西汀治疗原发性早泄的临床分析

英文题名：A study on treating primary premature ejaculation with the Xinfu lotion plus dapoxetine hydrochloride

作者：剡锐[1];张爱平[2];邢喜平[3]

第一作者：剡锐

机构：[1]兰州大学第一医院,甘肃兰州730020;[2]庆阳市中医医院,甘肃庆阳745099;[3]甘肃中医药大学附属医院,甘肃兰州730020

第一机构：兰州大学第一医院,甘肃兰州730020

年份：2024

卷号：16

期号：14

起止页码：122

中文期刊名：中医临床研究

外文期刊名：Clinical Journal Of Chinese Medicine

基金：兰州市科技指导性计划项目(2023-ZD-102);兰州大学第一医院院内基金(ldyyyn2022-70)。

语种：中文

中文关键词：原发性早泄;辛扶洗剂;达泊西汀

外文关键词：Primary premature ejaculation;The Xinfu lotion;Dapoxetine hydrochloride

摘要：目的:探讨辛扶洗剂联合达泊西汀治疗原发性早泄的临床疗效。方法:选取2021年10月-2022年6月甘肃中医药大学附属医院及兰州大学第一医院男科门诊收治的100例符合纳入标准和排除标准的原发性早泄的患者,按随机数字表法分为治疗组与对照组,每组50例。两组均采用达泊西汀治疗,治疗组在对照组基础上给予辛扶洗剂外泡阴茎龟头及阴茎体治疗,两组患者均治疗3个月。记录两组用药前后平均阴道内射精潜伏期(Intravaginal Ejaculatory Latency Time,IELT)、早泄诊断量表(Premature Ejaculation Diagnostic Tool,PEDT)(最广泛)评分、配偶满意度及不良反应,检测震动感觉阈值(Vibration Perception Threshold,VPT)-阴茎敏感度、患者血清睾酮水平。结果:治疗组和对照组总有效率分别是85.4%(41/48)、76.6%(36/47),差异具有统计学意义(P<0.05)。与治疗前相比,两组患者治疗后的IELT、PEDT评分、配偶满意度均有显著提高(P<0.05),阴茎龟头3点、6点、9点、12点处VPT值明显上升(P<0.01)。治疗后,治疗组的IELT、PEDT评分、配偶满意度较对照组改善更明显(P<0.05),龟头3点、6点VPT值上升更显著(P<0.01),两组龟头9点、12点VPT值差异无统计学意义(P>0.05)。治疗前后两组间血清睾酮水平比较差异无统计学意义(P>0.05)。结论:辛扶洗剂联合达泊西汀改善原发性早泄安全、有效,值得临床推广应用。
Objective:To explore the clinical efficacy of the Xinfu lotion(辛扶洗剂)and dapoxetine hydrochloride on primary premature ejaculation.Methods:A total of 100 patients with primary premature ejaculation in the male outpatient clinics of the Affiliated Hospital of Gansu University of Traditional Chinese Medicine and the First Hospital of Lanzhou University were divided into the treatment group and the control group by the random number table method,with 50 patients in each.Both groups were treated with dapoxetine hydrochloride orally,and the treatment group was treated with the Xinfu lotion for soaking penis glans and penis body.Both groups were treated for 3 months.The intravaginal ejaculation latency(IELT),premature ejaculation diagnostic tool(PEDT)score,spousal satisfaction and adverse reactions were recorded before and after medication in both groups,and the vibration perception threshold(VPT)-penile sensitivity and serum testosterone of the patients were measured.Results:The total efficiency was 85.4%(41/48)in the treatment group and 76.6%(36/47)in the control group,with statistically significant differences.Compared with before treatment,the IELT,PEDT score,and spousal satisfaction were increased significantly after the treatment(P<0.05),and VPT values of glans penis at 3,6,9 and 12 points were increased significantly(P<0.01)in both groups after treatment.After treatment,the amelioration of IELT,PEDT score,spousal satisfaction in the treatment group was more significant than those in the control group(P<0.05),and VPT values of the glans penis at 3 and 6 points in the treatment group were increased significantly(P<0.01),while the differences in VPT values of the glans penis at 9 and 12 points between two groups were not statistically significant(P>0.05).There was no differences in serum testosterone between the two groups and within each group before and after the treatment(P>0.05).Conclusion:The Xinfu lotion plus dapoxetine hydrochloride is safe and effective on primary premature ejaculation,and is worthy of clinical promotion.