文献类型：期刊文献

英文题名：Electrical stimulation: a novel adjunct therapy for diabetic foot ulcers

作者：Liu, Yuanjun[1];Liu, Xiaoyu[1];Lu, Jin[1];Jiang, Yunnan[1];Wu, Jian[2]

第一作者：刘永洁

通信作者：Wu, J[1]

机构：[1]Gansu Univ Chinese Med, Clin Sch Med 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Burns Surg Ward 2, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Burns Surg Ward 2, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：6

外文期刊名：FRONTIERS IN CLINICAL DIABETES AND HEALTHCARE

收录：Scopus(收录号：2-s2.0-105028214114);WOS:【ESCI(收录号:WOS:001665599200001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This study was supported by the Gansu Provincial Science and Technology Program (Grant No. 23YFFA0050 and No 21JR7RA674), the Lanzhou Municipal Science and Technology Plan Project (Grant No. 2023-ZD-29), and the Intramural Research Fund of Gansu Provincial Hospital (Grant No. 23GSSYB-13).

语种：英文

外文关键词：diabetic foot ulcers; direct current stimulation; electrical stimulation; pulsed electric current; wound healing

摘要：Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes; its healing is typically protracted and marked by a high rate of recurrence. In recent years, electrical-stimulation (ES) therapy has emerged as a novel adjunct to conventional approaches such as debridement, negative-pressure wound therapy, and moist dressings. By applying an exogenous electric field that mimics the skin's endogenous wound currents, ES provides directional cues for cells and signaling molecules involved in repair, guiding them toward the wound bed. The external field reconstructs the bioelectric landscape, inducing oriented migration and proliferation of keratinocytes, fibroblasts, and endothelial cells, while up-regulating factors such as HIF-1 alpha and VEGF to relieve local ischemia and promote neovascularization. Cathodal currents can also dampen the inflammatory cascade and facilitate the shift of macrophages from the M1 to the pro-healing M2 phenotype. The advent of nanogenerators, conductive hydrogels, and wireless "smart" bandages is gradually freeing ES from hard-wired leads, paving the way for home-based, closed-loop wound care. This review summarizes the latest mechanistic insights and device innovations, providing a reference for future clinical optimization and multicenter trials.