文献类型：期刊文献

英文题名：Characterization of Solid Tumors Induced by Polycyclic Aromatic Hydrocarbons in Mice

作者：Wang, Qiulan[1];Xue, Yongjie[2]

第一作者：王秋兰

通信作者：Xue, YJ[1]

机构：[1]Gansu Univ Chinese Tradit Med, Clin Coll, Lanzhou, Gansu, Peoples R China;[2]San Tang Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学临床医学院

通信机构：[1]corresponding author), San Tang Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China.

年份：2015

卷号：21

起止页码：81

外文期刊名：MEDICAL SCIENCE MONITOR BASIC RESEARCH

收录：Scopus(收录号：2-s2.0-84964699050);WOS:【ESCI(收录号:WOS:000399157000014)】；

基金：This work was supported by the Natural Science Foundation of Gansu Province, China (Grant No. 145RJZA235) and the Fundamental Research Funds for the Universities in Gansu Province

语种：英文

外文关键词：Bay-Region; Polycyclic Aromatic Hydrocarbon; Hydrocarbons; Mice, 129 Strain; Carcinoma, Acinar Cell; Immunologic Factors

摘要：Background: To assess the effects of single polycyclic aromatic hydrocarbons (PAHs) on solid tumor initiation, and investigate their roles in immune response regulation. Material/Methods: Mice (100) were randomly divided into 5 groups (n= 20) to be intraperitoneally injected with 10 daily doses of DMSO (control), anthracene (50 mg/kg), benzo-(a)-pyrene (10 mg/kg), benzo-(a)-pyrene (20 mg/kg), and benzo-[G, H, I])-perylene (5 mg/kg), respectively. Three months later, serum IL-2 and IL-6 levels were assessed by ELISA; liver, kidney, stomach and lung tissues were subjected to histopathological examinations. Results: Liver cancer incidences after benzo-[ G, H, I]-perylene, benzo-(a)-pyrene (10 mg/kg), benzo-(a)-pyrene (20 mg/kg), and anthracene were 21.1, 26.3, 35.3, and 27.8%, respectively; 21.1, 0, 41.2, and 0% showed stomach cancer, respectively; 0, 0, 11.8 and 0% displayed kidney cancer, respectively. The occurrences of precancerous liver lesions for benzo-[G, H, I]-perylene, benzo-(a)-pyrene (10 mg/kg), benzo-(a)-pyrene (20 mg/kg) and anthracene groups, respectively, were 68.4, 73.7, 64.7, and 55.6%; 78.9, 68.4, 29.4, and 27.8% showed precancerous stomach lesions, while 42.1, 47.4, 58.8, and 33.3% had precancerous kidney lesions; respectively. No obvious lung lesions were found in any group. Serum IL-2 and IL-6 levels in treatment groups were significantly lower compared with control values (P< 0.01). Conclusions: PAHs induce cancer and precancerous lesions in the liver, stomach, and kidney. Benzo (a) pyrene initiates gastric cancer in a dose-dependent manner, but does not induce precancerous lung lesions. Lower IL-2 and IL-6 levels in treatment groups compared with controls suggest that PAHs cause overt immune inhibition.