文献类型：期刊文献

中文题名：逍遥散及其拆方对老年性痴呆模型小鼠学习记忆能力及抗氧化能力的影响

英文题名：The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice

作者：吴红彦[1];王虎平[1]

第一作者：吴红彦

机构：[1]甘肃中医学院

第一机构：甘肃中医药大学

年份：2009

期号：10

起止页码：102

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2008】；

语种：中文

中文关键词：逍遥散;拆方;老年性痴呆;学习记忆能力;潜伏时间;超氧化物歧化酶;丙二醛

外文关键词：Xiaoyao San; splited prescription; AD; ability of learning and memory; latency; SOD; MDA;

摘要：目的:研究逍遥散对D-半乳糖(D-gal)所致老年性痴呆(AD)模型小鼠学习记忆能力及血清超氧化物歧化酶(SOD)活性、脑组织丙二醛(MDA)含量的影响,探讨逍遥散防治AD的作用及其机制。方法:采用ip D-gal复制AD小鼠模型,同时用逍遥散全方组、疏肝健脾组、疏肝养血组、健脾养血组进行对抗治疗,共42 d。41 d进行学习能力训练,42 d进行记忆能力测试。然后取血及脑组织,测定小鼠血清SOD活性及脑组织MDA含量。结果:全方组、疏肝健脾组、疏肝养血组、健脾养血组均可提高小鼠学习记忆能力,降低潜伏时间,但以全方组最为明显;全方组、疏肝健脾组、疏肝养血组、健脾养血组皆可提高血清SOD活性,降低脑组织匀浆MDA含量,但亦以全方组最为明显。结论:逍遥散能较好的改善AD模型小鼠行为学指标,其可能与对抗自由基氧化有关。
Objective： To investigate the effect of Xiaoyao San and it＇s splited prescription on the ability of learning and memory,SOD in blood serum, MDA in brain tissue of Alzheimer＇s Disease（AD） model mice made by D-gal and discuss the function and mechanism that Xiaoyao San defend AD. Methods： Using inject D-gal to make AD model mice while cured by Quanfang group, Shugan Jianpi group, Shugan Yangxue group, Jianpi Yangxue group of Xiaoyao San for 42 days. In the 41st day, make training of ability of leaming and memory, in the 42nd day, test ability of learning and memory, then, collect blood and brain tissue to mensurate SOD in blood serum, MDA in brain tissue. Results： Quanfang group, Shugan Jianpi group, Shugan Yangxue group, Jianpi Yangxue group of Xiaoyao San could improve ability of learning and memory and reduce the latency, but Quanfang group was the most obvious. Quanfang group, Shugan Jianpi group, Shugan Yangxue group, Jianpi Yangxue group of Xiaoyao San could increase SOD in blood serum and reduce MDA in brain tissue, but Quanfang group is the most obvious too. Conclusions： Xiaoyao San can amend the behavioral index of AD model mice and that may be relate to antioxidation.